University of Windsor - Academic Calendar, 1998 - 1999 
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GENERAL INFORMATION 

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GLOSSARY 
 

 4.4 Chemistry and Biochemistry

(Ext. 3521) 
OFFICERS OF INSTRUCTION 
Professors Emeritii 
Thibert, Roger J.; B.A. (Western Ontario), M.S. (Detroit), Ph.D. (Wayne State), F.C.I.C.-1953. 

McGarvey, Bruce R.; B.A. (Carleton College), M.A., Ph.D. (Illinois), F.C.I.C.-1972. 

Tuck, Dennis G.; B.Sc., Ph.D., D.Sc. (Durham), F.C.I.C., F.R.S.C. (U.K.)-1972. 

Professors 
McIntosh, John M.; B.Sc. (Queen's), Ph.D. (M.I.T.), F.C.I.C.-1968. 

Drake, John E.; B.Sc., Ph.D., D.Sc. (Southampton), F.C.I.C.-1969. 

Taylor, Keith E.; B.Sc., Ph.D. (Toronto)-1976. 

Mutus, Bulent; B.Sc., M.Sc. (Waterloo), Ph.D. (Manitoba)-1982. 

Stephan, Douglas W.; B.Sc. (McMaster), Ph.D. (Western Ontario) F.C.I.C.-1982. 

Aroca, Ricardo; B.Sc. (Chile), Ph.D. (Moscow State), D.Sc. (Leningrad)-1985. 

Loeb, Stephen J.; B.Sc., Ph.D. (Western Ontario), F.C.I.C.-1990. 

Jones, William E.; B.Sc., M.Sc. (Mount Allison), Ph.D. (McGill)-1991. (Vice President, Academic) 

Szabo, Arthur G.; B.Sc. (Queen's), M.A., Ph.D. (Toronto), F.C.I.C.-1993. 

Associate Professors 
Rumfeldt, Robert C.; B.Sc. (Loyola, Montreal), Ph.D. (Alberta)-1965. 

Hencher, J. Lawrence; B.A., Ph.D. (McMaster)-1967. 

Adeli, Khosrow; B.Sc. (Tehran), M.Sc., Ph.D. (Ottawa), Dipl. Clin. Chem. (Toronto)-1988. 

Lee, Lana; A.B. (Mount Holyoke), Ph.D. (Alberta)-1986. 

Green, James R.; B.Sc. (Windsor), Ph.D. (Waterloo)-1989. 

Christopoulos, Theodore K.; B.Sc., Ph.D. (Athens), Dipl. Clin. Chem. (Toronto)-1992. 

Antonelli, David M.; B.Sc., Ph.D. (Alberta)-1997. 

Assistant Professor 
Dutton, Philip J.; B.Sc., Ph.D. (Victoria)-1991. 

Adjunct Professors 
Draisey, Thomas F.; M.B., Ch.B. (Bristol), F.R.C.Path.; Department of Pathology, Hotel Dieu Grace Hospital and Windsor Western Hospital Centre-1969. 

Taylor, Norman F.; B.A., M.A., D.Phil. (Oxon), F.R.S.C. (U.K.)-1973. 

Spitz, Werner U.; M.D. (Hadassah), Pathologist, Macombe Munroe Counties Medical Examiner-1978. 

Foreback, Craig C.; B.A. (South Florida), Ph.D. (South Florida); Director of Clinical Chemistry, Henry Ford Hospital, Detroit -1986. 

Yee, George E.; M.D. (Manitoba), F.R.C.Path.; Medical Director, Medical Laboratories of Windsor-1986. 

Cheung, Raphael M.C.; M.D. (Toronto), F.R.C.P.(C); Medical Director, Lipid Clinic, Windsor Western Hospital-1988. 

Drury, Craig F.; B.Sc., M.Sc. (McGill), Ph.D. (Guelph); Soil Microbiologist, Agriculture Canada Research Station, Harrow-1991. 
Kovacs, Gregory J.: B.Sc., M.Sc., Ph.D (Toronto)-1991. 

Nazri, Gholam Abbas; B.S., M.S. (Tehran), Ph.D. (Case Western Reserve), Scientist, General Motors Research, Warren-1991. 

Artiss, Joseph D.; B.Sc., Ph.D. (Windsor); Associate Professor of Pathology, Wayne State University-1993. 

Yee, Hugh; B.S., M.S., Ph.D. (Wayne State); Technical Director   Toxicology, DMC University Laboratories, Detroit-1993. 

Shore, Joseph; B.S. (Cornell), M.S. (Massachusetts), Ph.D. (Rutgers), Department of Pathology, Henry Ford Hospital, Detroit-1996. 

Keys, Stephen.; B.Sc. (Toronto), Ph.D. (British Columbia), Fellowship in Clinical Chemistry (Windsor), FCACB-1997. 

4.4.1 PROGRAMS OF STUDY 

Preparation for Graduate and Professional Schools 
Courses are available to permit the student to become fully prepared for entry into medical, dental, and pharmacy schools, as well as graduate programs in the physical and life sciences. Students should determine as early as possible the specific requirements for graduate or professional schools and programs that they may wish to apply for after completing all or part of a Chemistry or Biochemistry program. (See also 5.2.3.) Academic advisors are available. 

Languages Other Than English: Since many graduate schools have language requirements, students who may subsequently choose to enter graduate school are strongly advised to consider a selection of courses which includes the prominent scientific languages, French, German and Russian. 

Community College Graduates: Graduates of three year programs in Chemical Technology, Environmental Technology, Industrial Hygiene Technology and Medical Technology may be given substantial credit toward degree programs in Chemistry or Biochemistry. Detailed advice on these matters can be obtained from Chemistry and Biochemistry. 

Standing Required: For admission to any Chemistry or Biochemistry program at the second level, a student must obtain a minimum grade of C  in Chemistry 59 140 and 59 141, or the equivalent. Students in Biochemistry also must obtain a minimum grade of C  in Biology 55 140 and 55 141. Furthermore, for admission to and continuation in any honours program a student must have and maintain a minimum major average of 8.0 and a cumulative average of 5.0. 

The three honours programs offered by Chemistry and Biochemistry are accredited by the Chemical Institute of Canada. 

PROGRAM REQUIREMENTS 
1) The prerequisite for 59 400 and 59 410 is a major G.P.A. of 8.0. 

2) Unless otherwise stated, students in Chemistry and Biochemistry are expected to take the course with laboratory where two offerings differing only in the presence or absence of a laboratory component are listed. 

Chemistry Major 
Total courses: forty. 
Major requirements: twenty courses, including 59 140, 59 141, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 261, 59 320, 59 321, and nine additional courses at the 300 or 400 level. 

Other requirements: 
(a) 62 120, 62 140, 62 141, 64 140, 64 141, and 64 220. 
(b) four courses from Arts, Languages or Social Science; 
(c) ten courses from any area of study. (62 215 and 62 216 are strongly recommended.) 

RECOMMENDED COURSE SEQUENCE 
Level 1: ten courses, including 59 140, 59 141, 62 120, 62 140, 62 141, 64 140, 64 141. (Recommended: 60 104 or 64 151.) 

Level 2: ten courses, including 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 261, and 64 220. 

Levels 3 and 4: twenty courses, including 59 320, 59 321, 59 400, and 59 410; and six additional Chemistry and Biochemistry courses. (Recommended: 62 215 and 62 216.) 

Chemistry and Physics Major 
Total courses: forty. 
Major requirements-Chemistry and Biochemistry: sixteen courses, including 59 140, 59 141, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 320, 59 321, 59 330 (or 59 331), and 59 342; plus four other courses. 

Major requirements-Physics: fourteen courses, including 64 140, 64 141, 64 151, 64 220, 64 221, 64 222, 64 250, 64 261, 64 310, 64 315, 64 323 (or 64 320), and 64 331; plus two other courses at the 300 or 400 level.

Other requirements: 
(a) 62 120, 62 140, 62 141, 62 215, 62 216, and 62 218; 
(b) two courses from Arts, Languages, or Social Science; 
(c) two courses from any area of study. 
 
RECOMMENDED COURSE SEQUENCE 
Level 1: ten courses, including 59 140, 59 141, 62 120, 62 140, 62 141, 64 140, 64 141, and 64 151. 

Level 2: ten courses: 59 230, 59 235, 59 240, 59 241, 62 215, 62 216, 62 218, 64 220, 64 221, and 64 222. 

Level 3: ten courses, including 59 250, 59 251, 59 342, 64 250, 64 261, 64 310, 64 315, 64 323 (or 64 320), and 64 331. 

Level 4: ten courses, including 59 320, 59 321, and 59 330 (or 59 331); plus four additional Chemistry courses; and two additional Physics courses at the 300 or 400 level. 

Biochemistry Major 
Total courses: forty. 

Major requirements: twenty courses, including 59 140, 59 141, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 261, 59 320, 59 321, 59 360, 59 361, 59 365, and six additional courses at the 300  or 400  level. 

Other requirements: 
(a) 55 140, 55 141, 55 213, 55 238, 62 140, 62 141, 64 140, 64 141 and 60 104 (or 64 151). 
(b) four courses from Arts, Languages or Social Science; 
(c) seven courses from any area of study. 

RECOMMENDED COURSE SEQUENCE 
Level 1: ten courses, including 55 140, 55 141, 59 140, 59 141, 62 140, 62 141, 64 140, 64 141, and 60 104 (or 64 151). 

Level 2: ten courses, including 55 213, 55 238, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, and 59 261.

Level 3 and Level 4: twenty courses, including 59 320, 59 321, 59 360, 59 361, 59 365, 59 464, and 59 468; plus four additional courses from Chemistry and Biochemistry at the 300  or 400 level. 
Chemistry Honours 

In order to earn an Honours B.Sc. in Chemistry, students must also include the courses 59 400 (seminar) and 59 410 (research) within the "major requirements" as outlined for the Chemistry major program described above. It should be noted that only students who have maintained a major average of 8.0 and a cumulative average of 5.0 will be permitted to enrol in 59 400 and 59 410. 

Chemistry and Physics Honours 
In order to earn an Honours B.Sc. in Chemistry and Physics, students must include the courses 59 400 (seminar) and either 59 410 (research) or both 64 412 and 64 413 (research) within the "major requirements" as outlined for the Chemistry and Physics major program described above. It should be noted that only students who have maintained a major average of 8.0 and a cumulative average of 5.0 will be permitted to enrol in 59 400, 59 410, 64 412 and 64 413. 

Biochemistry Honours 
In order to earn an Honours B.Sc. in Biochemistry, students must also include the courses 59 400 (seminar) and 59 410 (research) within the "major requirements" as outlined for the Biochemistry Major program described above. It should be noted that only students who have maintained a major average of 8.0 and a cumulative average of 5.0 will be permitted to enrol in 59 400 and 59 410. 

Combined Major Programs 
Programs combining Chemistry with another major will consist of the following: 

Total courses: forty. 

Major requirements-Chemistry and Biochemistry: fifteen courses, consisting of 59 140, 59 141, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 261, 59 320, 59 321, 59 330 (or 59 331), and 59 340; plus two additional courses at the 300  or 400 level. 

Major requirements-Other Subject: as prescribed by that area of study. 

Other requirements: 
(a) 62 120, 62 140, 62 141, 64 140, 64 141 and 64 220; 
(b) additional courses, if necessary, from any area of study to a total of forty courses. 

Programs combining Biochemistry with another major will consist of the following: 

Total courses: forty. 

Major requirements-Chemistry and Biochemistry: fifteen courses, consisting of 59 140, 59 141, 59 230, 59 235, 59 240, 59 241, 59 250, 59 251, 59 261, 59 320, 59 321, 59 360, 59 361, 59 365, and one additional course at the 300  or 400 level. 

Major requirements-Other Subject: as prescribed by that area of study. 

Other requirements: 
(a) 55 140, 55 141, 55 243, 62 140, 62 141, 64 140, and 64 141; 
(b) additional courses, if necessary, from any area of study to a total of forty courses. 

Chemistry and Biochemistry Minor 
The minors in Chemistry and in Biochemistry consist of six courses, including 59 140 and 59 141, plus three courses at the 200 level or above, and at least one course at the 300 level or above. If the minor is in Biochemistry, at least three of 59 261, 59 360, 59 361, 59 365, 59 464 and 59 468 must be chosen. Selected courses leading to a minor in either area may not consist of antirequisites to courses in the student's degree program. Where two offerings of a course differing only in the presence or absence of a laboratory are available, students are expected to select the one with the laboratory. Students must also remember to select only courses which may be otherwise counted for credit towards their degree programs. 

4.4.2 COURSE DESCRIPTIONS 

All courses listed will not necessarily be offered each year. 

The prerequisite of all 200 level courses, unless otherwise indicated, will be both 59 140 and 59 141. 

The prerequisite for all 400 level courses will be the consent of the instructor, except as noted. 

59 110. Topics In General Chemistry 
An introduction to selected topics in modern chemistry for science and engineering: properties of matter and solutions, stoichiometry, equilibrium theory and applications, oxidation reduction reactions, rate processes, atomic and molecular structure. (Prerequisite: OAC Chemistry.) (3 lecture, 3 laboratory hours a week.) 

59 140. General Chemistry I 
Introductory concepts in chemistry, including reactions of atoms, ions, and molecules, solution stoichiometry, thermochemistry, electronic structure of atoms, basic chemical bonding and molecular geometry, periodic properties of the elements, and the theory of gases. (Prerequisite: OAC Chemistry or consent of the instructor.) (3 lecture, 3 laboratory/tutorial hours a week.) 

59 141. General Chemistry II 
A continuation of 59 140 covering topics such as chemical kinetics, general equilibrium theory, acid base theory, chemical thermodynamics, and introduction to organic chemistry. (Prerequisite: 59 140.) (3 lecture, 3 laboratory/tutorial hours a week.) 

59 191. Organic and Biological Chemistry for Health Sciences 
A course of particular interest to students of nursing and other health science areas. The subject matter includes a survey of organic functional groups, the organic chemistry of biomolecules, and a survey of the major metabolic pathways. (Prerequisite: OAC Chemistry.) (Antirequisites: 59 141, 59 230, and 59 232.) (2 lecture hours, 1 tutorial hour a week.) 

59 201. Chemistry in the Marketplace 
The basic notions of Chemistry will be introduced and discussed in a qualitative manner with a view to understanding chemistry and materials encountered in everyday life. The course will provide an appreciation for the ubiquitous nature and importance of chemicals and chemical processes. Discussion will include a variety of topics such as chemistry in the home, plastics, drugs, cosmetics, biotechnology, chemistry and computer technology, nuclear power and pollution. The course is intended for students with no formal background in chemistry. (Not open to first year students; may be taken by B.Sc. students for credit, but it does not count as Chemistry and Biochemistry course or other science option towards the fulfilment of the requirements for the B.Sc degree.)(2 lecture hours a week).

59 230. Introductory Organic Chemistry 
Introduction to organic chemistry, with emphasis on structure, stereochemistry, and reactions of aliphatic and alicyclic compounds and their functionalized derivatives. (Prerequisites: 59 140 and 59 141.) (Antirequisite: 59 232.) (3 lecture, 3 laboratory hours a week.) 

59 232. Introductory Organic Chemistry 
The same as 59 230 but without the laboratory. (Prerequisites: 59 140 and 59 141) (Antirequisite: 59 230.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.) 

59 235. Introductory Organic Chemistry II 
A continuation of 59 230. Topics include the chemistry of nitrogen containing compounds, aromatic chemistry and an introduction to spectroscopic methods. (Prerequisite: 59 230.) (2 lecture hours a week.) 

59 240. Introductory Physical Chemistry I 
The laws of thermodynamics applied to changes of state and chemical reactions. Spontaneous processes. (Prerequisites: 59 140, 62 140, and 62 141.) (3 lecture, 1.5 laboratory hours a week.) 

59 241. Introductory Physical Chemistry II 
Physical and chemical equilibrium, electrochemistry. (Prerequisite: 59 240.) (3 lecture, 3 laboratory hours a week.) 

59 250. Introductory Inorganic Chemistry I 
Introduction to chemical bonding including molecular orbital and valence bond models and their application to the stereochemistry and properties of hydrides and halides. Photoelectron, NMR, and vibrational spectroscopy are introduced as complementary tools in the examination of these molecular species. (3 lecture, 1.5 laboratory hours a week.) 

59 251. Introductory Inorganic Chemistry II 
The coordination chemistry of transition metals will be discussed, with particular reference to the means of physical and spectroscopic characterization. Relevance of such compounds to bio inorganic systems will also be discussed. (Prerequisite: 59 250.) (3 lecture, 3 laboratory hours a week.) 

59 253. Introductory Inorganic Chemistry II 
The same as 59 251 but without the laboratory. (Prerequisite: 59 250.) (3 lecture hours a week.) 

59 261. Organic Chemistry of Biomolecules 
An extension of the principles covered in 59 230 to the structure and properties of organic molecules of biological significance. (Prerequisite: 59 230.) (3 lecture, 3 laboratory hours a week.) 

59 263. Organic Chemistry of Biomolecules 
The same as 59 261 but without the laboratory. (Prerequisites: 59 230 or 59 232 or consent of instructor.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.) 

59 291. Pharmacology for Health Sciences 
A course of particular interest to students of nursing and other health science areas. The principles of pharmacokinetics and pharmacodynamics will be covered utilizing a systems approach to pharmacologic therapies in health care. (Prerequisites: 55 204, 55 205, and one of 59 191, 59 261 and 59 263.) (2 lecture hours, 1 tutorial hour a week.) (May be taken by B.Sc. students for credit, but does not count as a Biochemistry course towards the fulfillment of the requirements for the B.Sc. degree.) 

59 320. Analytical Chemistry 
Solution chemistry. Precipitation, complexation, electron transfer, and proton transfer reactions. Potentiometric, polarographic and amperometric titration techniques. Data analysis and chemical statistics. (Prerequisites: 59 141, 62 141, and 65 253, or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 

59 321. Principles of Instrumental Analysis 
Electronic and digital circuits. Microprocessor controlled instrumentation and microcomputer interfacing. Data acquisition and data processing in electrochemical and spectroscopic techniques. (Prerequisite: 59 320.) (2 lecture hours, 1 tutorial hour, 3 laboratory hours a week.) 

59 330. Intermediate Organic Chemistry I 
Structure elucidation and the use of spectroscopic techniques in organic chemistry. The laboratory portion focuses on synthetic chemistry, with application of spectroscopic methods. (Prerequisite: 59 235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 

59 331. Intermediate Organic Chemistry II 
The methods of organic synthesis and the reaction mechanisms involved. (Prerequisite: 59 235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.) 

59 332. Intermediate Organic Chemistry I 
The same as 59 330 but without the laboratory. (Prerequisite: 59 235 or consent of instructor.) (3 lecture hours a week.) 

59 333. Intermediate Organic Chemistry II 
The same as 59 331 but without the laboratory. (Prerequisite: 59 235 or consent of instructor.) (3 lecture hours a week.) 

59 340. Intermediate Physical Chemistry I 
Collisions, transport properties and rates of chemical reactions. (Prerequisite: 59 241.) (2 lecture, 3 laboratory hours a week.) 

59 341. Quantum Chemistry and Spectroscopy 
Introduction to quantum chemistry, rotational and vibrational spectroscopy of diatomic and polyatomic molecules, visible and ultraviolet and Raman spectroscopy. (Prerequisite: 59 340.) (3 lecture, 3 laboratory hours a week.) 

59 342. Intermediate Physical Chemistry I 
Same as 59 340 but without laboratory. (Prerequisite: 59 241 and consent of instructor.) (2 lecture hours a week.) 

59 343. Quantum Chemistry and Spectroscopy 
The same as 59 341 but without the laboratory. (Prerequisite: 59 340 or 59 342.) (3 lecture hours a week.) 

59 350. Intermediate Inorganic Chemistry 
An introduction to main group chemistry. This will start as a continuation of 59 250 and deal with a systematic examination of the structure and reactivity of simple and complex oxides and halides of the main group elements. Additional topics such as main group chains, rings, and cages, non aqueous solvents and main group organometallic compounds will also be discussed. (Prerequisite: 59 250.) (3 lecture, 3 laboratory hours a week.) 

59 351. Organometallic Chemistry 
The course will cover the structure, synthesis, spectroscopic properties, and reactivity of transition metal complexes which incorporate M C and M H bonds. The principles of bonding and fluxionality, as well as applications of this chemistry in catalytic processes of industrial interest will be discussed. (Prerequisite: 59 251.) (3 lecture, 3 laboratory hours a week.)

59 352. Intermediate Inorganic Chemistry 
The same as 59 350 but without the laboratory. (Prerequisite: 59 250.) (3 lecture hours a week.) 

59 353. Organometallic Chemistry 
The same as 59 351 but without the laboratory. (Prerequisite: 59 251 or 59 253.) (3 lecture hours a week.) 

59 360. Intermediary Metabolism I 
Catabolism and the generation of phosphate bond energy. Laboratory exercises are associated with the analytical and preparative procedures of biochemistry. (Prerequisite: 59 261.) (3 lectures, 3 laboratory hours a week.) 

59 361. Intermediary Metabolism II 
The utilization of phosphate bond energy will be illustrated by carbohydrate, fatty acid and lipid biosynthesis, hormonal (G proteins) and metabolite regulation, biological membranes (structure and transport mechanisms) and contractile processes (muscle biochemistry). (Prerequisite: 59 360.) (2 lectures, 3 laboratory hours a week.) (Limited enrolment.) 

59 362. Intermediary Metabolism I 
The same as 59 360 but without the laboratory. (Prerequisite: 59 261 or 59 263.) (3 lecture hours a week.) 

59 363. Intermediary Metabolism II 
The same as 59 361 but without the laboratory. (Prerequisite: 59 360 or 59 362.) (2 lecture hours a week.) 

59 365. Protein and Nucleic Acid Chemistry 
The covalent and three dimensional structures of these macromolecules will be described in conjunction with study of the chemical and physical methods used in their purification and characterization. (Prerequisite: 59 261.) (2 lecture hours a week.) 

59 400. Seminar 
Discussion of selected topics from the current literature. (1 lecture hour a week over two terms; 3.00 credit hours; under special circumstances may be completed in one term.) (Normally open to students in only Honours Chemistry, Honours Chemistry and Physics, or Honours Biochemistry.) 

59 410. Research 
Original laboratory research under the direction of a faculty member. (1 lecture, 12 laboratory hours a week) (A 6.00 credit hour course given over two terms.) (See above, "Program Requirements".) 

59 421. Advanced Analytical Chemistry 
Special topics in analytical chemistry. (2 lecture hours a week.) 

59 431. Special Topics in Organic Chemistry 
Topics may include polymer chemistry, natural product chemistry, advanced synthetic methodology, or design and execution of organic syntheses. (Prerequisite: 59 331 or consent of instructor.) (2 lecture hours a week.) 

59 435. Advanced Organic Chemistry 
Physical organic chemistry. Includes molecular orbital theory, stereochemistry, thermodynamics, and reaction mechanisms. (Prerequisite: 59 331 or consent of instructor.) (2 lecture hours a week.) 

59 440. Kinetics and Photochemistry 
Rates of reaction, theory and mechanisms, solution kinetics and photochemical kinetics. (2 lecture hours a week.) 

59 441. Statistical Thermodynamics 
Development of statistical thermodynamics and its application to theories of gases, condensed states and chemical equilibria. (2 lecture hours a week.) 

59 445. Advanced Physical Chemistry 
Special topics in physical chemistry. (2 lecture hours a week.) 

59 450. Group Theory in Chemistry 
Various applications of group theory to the study of organic and inorganic systems. (Prerequisite: 59 341, or 59 343, or consent of instructor.) (2 lecture hours a week.) 

59 451. Special Topics in Inorganic Chemistry 
Advanced topics in inorganic chemistry and organometallic chemistry may include analytical and spectroscopic methods of use to the inorganic chemist, advanced topics in main group chemistry, coordination chemistry, organometallic chemistry, or the chemistry of the lanthanides and actinides. (Prerequisite: 59 351 or 59 353.) (2 lecture hours a week.) 

59 464. Enzymology 
Mechanisms of enzyme action will be covered in terms of kinetics, functional groups responsible for catalysis and specificity and the design of active site directed irreversible inhibitors. (2 lecture hours a week.) 

59 466. Special Topics in Biochemistry 
(2 lecture hours a week.) 

59 468. DNA Science and Diagnostics 
An advanced lecture and laboratory course dealing with DNA science and the application of DNA technology in the understanding and diagnosis of human disease. The lectures cover the biochemistry and expression of DNA and RNA at the molecular level, the theory and practice of recombinant DNA technology, and the application of DNA probes in diagnosis of human disease. The laboratory component involves construction and cloning of a recombinant DNA molecule. (Limited enrolment.) 

59 470.  Advanced Quantum Chemistry 
Perturbation and variation theories. Theories of many electron atoms and general theories of chemical bonds in diatomic and polyatomic molecules. (Prerequisite: 59 341 or 59 343.) (2 lecture hours a week.) 

59 476. Special Topics in Chemistry 
(2 lecture hours a week.) 
 

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