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Embrology and Developmental Genetics

Devo-Dictionary


Editor: M. Crawford   Contributors: Class of 1999-2005
| Syllabus | Crawford Homepage | Assignments |355 Homepage | 455 Homepage | New Dictionary |

List of Gene Pages and their Authors

Alk4 (Activin like kinase receptor 4 - Xenopus) by S. Davis
AmphiHox3  (Amphioxus) by M. Peturson
Amyloid Protein (Alzheimer's as prion disrder) by Sylvie Tremblay
Aniridia (an2) see Pax6
Antennapaedia (Drosophila) by J. Fair & K. Piercell
APC( Adenomatous polyposis coli tumour suppressor in zebrafish) by E. Dueck
Apterous (Drosophila) by D. Habib
Aristaless and Distaless (Drosophila) by J. Anton and M. Verslycken
Arx  Aristaless-like homeobox (human) by J. Plumb
Arx Aristaless-like homeobox (mouse) by E. Montcalm
Arx  Aristaless-like homeobox (frog) by A. Malysa
Atr2 (Atrophin, RERE) (Mouse) by Y. Kita
Atv Antivin (Zebrafish) by S. Hirsi
axin2 (mouse, human) by J. Vergel de Dios
bicoid (Drosophila) by D. Leung
Blimp1 (B-lymphocyte-induced maturation protein-1, a histone methyltransferase) by A. Cox and B. Pridham
Bmi (mammalian polycomb gene) by J-P Morand
BMP-2 Bone Morphogenic Protein (Mouse) by S. Kim
BMP-4 (Mouse) by S. Dyck
BMP-4 (Chick) by P. Tartaro
BMP7(zebrafish) by K. Honey
Bon (Bonnie and Clyde Mix family transcription factor) (Zebrafish) by J. Skiba
Bra (brachyury - Tbox family of transcription factors) (frog) by J. Spratt
Cbfa (runt family of transcription factors - Mouse) by A. Pamula
Cdx2 (Mouse primarily with discussion of other organisms) by Yektami Akyol
Cdx4 (mouse caudal homolog) by S. Eberwein
Cerberus(Mouse) by A. Levi
cDermo1  (chick) by J Rocque and N. Wouters
Cdx2 and Stem Cell Sources (Human) by S. Newcomb
Chordin (Chd) (Xenopus) by Y. Fordjour
cKit (Mouse) by R. Ard, Paramutation (in cKit - mouse)
cnn (Centrosomin) (Drosophila) by K. Thickett
Cofilin (cfl1) (mouse) by C. Anderson
CREBBP (CREB Binding Protein) (Human) by N. Raihan
Cux1 (Cut homolog in Chick) by S. Wheeler
Cyp26(retinoic Acid degrading enzyme, mouse) by M. Duronio
Cyp26a1 (retinoic acid degrading enzyme, zebrafish) by S. Eberwien
Cyp26b1(retinoic acid degrading enzyme, mouse) by G. Dakhil
daf-16 forkhead transcription factor (C elegans) by V. Nguyen
dcr-1Dicer (C. elegans) by E. Harrison
decapentaplegic (dpp) (Drosophila) by M. Peyando
dHAND (Vertebrates) by V. Andjelkovski
Dentin Sialophospoprotein (DSPP, Drosophila) by E. Kalmantis
Dermo1 (cDermo - chick) by J Rocque and N. Wouters
Desert hedgehog (dhh, mouse) by S. Pennickara
Dnmt (DNA methyl transferase) (Mouse) by A. Oakey
Dicer see dcr-1 by E. Harrison
Distal-less Dlx5 (mouse) by A. Platt & J. Cuthbert
Dll3 (human and mouse) by S. Perko
Dlx5 (Distal-less) (mouse) by A. Platt & J. Cuthbert
DNMT 3B (DNA Methyltransferase 3B - Human) by E. Kalmantis
Doublesex (Drosophila) by S. Lai
dpp (Decapentaplegic) (Drosophila) by M. Peyando
DSPP (Dentin Sialophosphoprotein, Drosophila) by E. Kalmantis
Dvl 2 Dishevelled (wnt signal transducer in Mouse)  by I. Baran
EcR Ecdysone receptor (Drosophila) by L. Baker and P. Swan
EDAR and Ed1 (Ectodysplasin, and Ectodysplasin A Receptor )- (Mouse) by M. Narewal and A. Schell
Egfl7 (Epidermal Growth Factor-like) (Zebrafish) by S. Marchant
En2 (engrailed, mouse) by S. Tremblay
Ephrins, Ryk, Wnt3, and neural patterning (Chick) by N. Samaan
eyeless (eye in Drosophila) see Pax6 (human homologue) and twin of eyeless (toy - in Drosophila)
FGF1 (Fibroblast Growth Factor) by V. Rixon
FGF2 (various vertebrates) by D. Kokh
FGF4 (chick) by S. Brode
FGF8 (human) by J. Grando
FGF8 (Mouse) by J. Rankin & R. Saka
FGF8 (zebrafish) by T. Howlett
FGF10 (Human) by K. Neal and S. Warriach
FGF10 (mouse) by N. Wright
FGF10 (Chick) by S. Miskin
FGFr(FGF receptor - mouse) by J. Harris
FGFr1 (mouse) by P. Rizk
FGFr2 (mouse/human) by M. Urbanski
FGFr3 (mouse/human) by T. Ohman
FMR1(Fragile X Syndrome) Human) by S. Perko
Fog (folded gastrulation) (Drosophila) by S. Dopazo
Follistatin (Rat) by P. Ward
Foxa2 (mouse) by T. Noone
Foxp2 (Human) by J. Zazula and C.J. Agres
FOXO (Drosophila) by C. Denomme &  L. Henderson
Foxo1 (mouse) byJ. Byrne
Ftz (Fushi tarazu in Centipede) by W. Wong
Frizzled (Xenopus) by S. Sovran
Frizzled 6 (Mouse) by S. Petrykowski
GATA5 (zebrafish) by R. Kooner
Gbx2(Xenopus) by N. Koutelas & M.M. Alvarez
Gbx2 (Mammal) by E. Meyer
Geminin (general listing) by S. Shukoor
Gli1 (zinc finger domain transcription factor) by V.A. Chitte & E. Brokalakis
Gli3 (chick, mouse, human) by S. Wilkki
Gremlin (Human and others) by L. Shrum
Goosecoid (Gsc) (Mouse) by C. Smith
H+ K+ Pump and laterality by S. Squire
H19 (human) by M. St. Pierre
H19 (mouse) by L. Bryk
Hairy enhancer/Split1 and 7 (her1, her7) (zebrafish) by A. Lumani
HAT ( Tip 60 a myst Histone Acetyl transferase) (mouse) by S. Petrinac
HDAC  Zm Rpd3(a Histone Deacetylase) (Zea mays) by C. Chen
Hedgehog (Drosophila) by S. Perry and by H. Bos
Hemoglobin -Fetal disorder (HFHD)  (Human) by N. Jun
Heparan Sulphate (Drosophila) by  C. Russo
Her1 and 7 (Hairy enhancer/Split) (zebrafish) by A. Lumani, or Her1 specifically by S. Newcomb
Hermes (Xenopus) by L. Theriault and L. Balallo
Hesx1  (Mouse) by K. Mastromettei & R. Chan
HFHD see Hemoglobin by N. Jun
Histone acetyl transferase (see Tip 60 a myst Histone Acetyl transferase - HAT) (mouse) by S. Petrinac
Histone deacetylase (HDAC see Zm Rpd3 in corn)
Hlx (various) bi C. Christie
Hothead mutation reversion (Arabidopsis )
Hox Genes and Limb Evolution by C. Luu
Hox B cluster (primarily early gees in chick) by A. Purushottam
HOXA1 (humna) by M Reis et al..
Hoxb1 (Zebrafish) by B. Dufour
Hoxa-4 (Mouse) by T. Dube
Hoxd4 (mouse) by J. Simmons et al.
Hoxc-8 (Mouse) by S. Caputo
Hoxd-10 (mouse) by M. Sharon
Hox11 Compound knockouts (mouse) by M. Madra, and Hoxd-11 specifically, by K. McDowell
Hoxa-13 (mouse) by S. Thangavel
Hoxd-13 (mouse and human) by J. Marentette & M. Klymko
HPRT1 (Lesch-Nyhan syndrome, humans) by L. Bauer
HSP 70 Heatshock protein 70 (zebrafish) by S. McMaster
Hunchback (hb) by D. C. Reaume
Huntington's Disease Gene Homolog (Mouse) by M. Chan
IGF2 (Insulin-like growth factor II, Mouse) by K. Withers
Indian Hedgehog (Chick) by S. Jaggi.
Integrin b-1 and Hirschsprung disease (human) by P. Rizk
jmj jumanji (mouse) by R. Marshall and L. Lenarduzzi
Keratin (Chicken) by K. Quinn
Kit (Mouse) by R. Ard
KrKruppel (Drosophila) by M. Ganuelas
KRIT1 (Cerebral Cavernous Malformation) by J. Saso
KRIT1 (Cerebral Cavernous Malformation) by J. Martin
Krox-20 (Mouse) by H. Brennan
Lbx1 (Mouse) by K. Wakem
LEF1 (Human and mouse) by E. Kirou and S. Karemera
Lefty1 (Vertebrates) by L. D'Alessandro
Let7 (miRNA in Zebrafish) by N. Samaan
Let7 (short RNA - C. elegans) by A. Van Delinder
Lhx3 (Lim gene in Mouse) by T. Mulcaster
Lim (dlim) (Drosophila) by M. Salem
lin-12 (Notch) by L. Jacobs
Liv1 (Leucine-isoleucine-valine-1 transporter) (Zebrafish) by S. Hills
Lunatic Fringe (Mouse) by J. Rosati
MAPT (Microtubule-Associated Protein Tau - Human) by O. Halitsky
Mef2 (mouse) by S. Brew
Meso (chick) by S. Chang
mir (mirror) - iroquois-related transcription factor (Drosophila) by J. Willans
mir 430 (miRNA in Zebrafish) by K. Kwiatkowska
miRNA (micro RNA in mouse) by B. Bogucki
MITF (micropthalmia gene - Mouse and Human) by F. Cristofanilli
MSX-1 (Mouse) by G. Adams
Msx1 (Xenopus) by K. Ly
MSX-2 (Chick, Mouse, Human) by L. Morvay
Nanog (Mouse) by F. Taboun
Nap (Nucleosome assembly protein, mouse) by M. Le
NCoR2 (SMRT, Xenopus) by J. Bustamante and another by S. Kipping
NF-kB (Chick) by D. Olujic
Nkx2.2b(Zebrafish) by T. Hogan
Nkx2.5 (Xenopus) by R. Di Gregorio
nodal (mouse) by A. Ellwood
Nodal/squint (zebrafish) by J. Charlebois
noggin (Mouse, Xenopus) by A. Lemmo
noggin (Xenopus) by J. Walker
Notch (general description in animals as diverse as Drosophila to vertebrates) by P. DiPasquale
no turn (Mouse) by J. Vandervelden
Oct-4(Mouse) by H.L. Liu
Orthodenticle (Drosophila) by L. Voltic
Otx1 (Lamprey) by M. Dattilio
Otx2(Mouse) by J. Boismier
Otx2 (Mouse) by J. Borbely
p63 (mammals) by W. Tashakor
Pax6 (Xenopus and Drosophila) by E. Mottillo or
Pax6 (mammals) by J. Lyons,
Pax6 (blind cavedwelling fish) by M. Simms
Pax6 (Chick) by M. St. Pierre
Pax7 (Mouse) by L St. Louis
Pbx1 (mouse) by C. Velsamy & J. Rouffer
Pitx1 (Mouse jaw and Hindlimb development) by C. DaSilva
Pitx2 (Chick, Mouse) and with emphasis on laterality   by A. Mosca A. Sydor,  M. Ienna
Pitx2 (Xenopus) by L. Baker
Pitx3 (REIG) (mouse) by C. Braccio
Proboscipedia (Drosophila) by J. Girard
Prospero (Drosophila) by G. Chidiac
PTCH (Patched - sonic hedgehog receptor) by A. Del Rizzo
RALDH1 (mouse) by A. Mulaosmanovic and A. Chan
RALDH2  (Raldh2 - Mouse) by B. van Beek
Raldh2 (zebrafish) by M. Franczak
Raldh3 (mouse) by L. Berthiaume
RAR-alpha Retinoic Acid Receptor (mouse) by D. Bravo de Laguna
RAR-beta (Rat) by A. Firby
RAR-beta (mouse) by S. McBean
RAR-gamma Retinoic acid receptor (Xenopus) by I. Magine
reaper (Drosophila) by K. Upcott & R. Page
rel (Chicken) by A. Hussain
Retinaldehyde dehydrogenase type II  (Raldh2 - Mouse) by B. van Beek
Retinaldehyde dehydrogenase type II (Raldh2 zebrafish) by M. Franczak
Retinaldehyde dehydrogenase type 3 (Raldh3 mouse) by L. Berthiaume
Rnf2 Ring Finger Protein 2 (polycomb group) (Mouse)  by M. Baker
Rx (or xRx1 from Xenopus) by N. Patel
Rx3 (medaka fish) by K. Frederick
Rx3 (zebrafish) by E. Rizk  and A. Urquhart
RXR-gamma (Mouse) by C. Comstock
RXR-alpha(Mouse) by W. Assaily
Ryk, Wnt3, Ephrins, and neural patterning (Chick) by N. Samaan
Sevenless (sev - Drosophila) by A. Chan
Shh - Sonic Hedgehog (Chick) by S. Whalen or by J. Patel, or in mouse by A. Mehta & E. Ross & C. Beaumont
SHH and pancreas specification (mammals) by S. Stanic
Sine oculis (Drosophila) see so
Six3 (mouse) by S. Nickelson
Six3 (medaka fish) by P. Lemire
Six4 (Drosophila) by C. Iaquinta
Slug (Chick) by  B. Belczowski  & B. Neufeld
Smad1(Mouse) by S. O'Rourke
Smad2 (Drosophila) by C. Stewart
so (Drosophila) by A. McGregor
SOHo (Chick and Mouse)  by B. Liszewski
Sonic hedgehhog - Sonic Hedgehog (Chick) by S. Whalen or by J. Patel, or in mouse by A. Mehta & E. Ross & C. Beaumont & Z. Avci
Sonic Hedgehog (SHH, Human) by S. Palombo
Sox2 (Human) by E. Bailey
Sox8 (mouse) by K. Fantetti
Sox9 (Xenopus) by K. Myslik
Sox9 (Mouse) by R. Provost
Sox9 (Human) by A. Shah
Sox10 (Homo sapiens) by S. Squire
Sox13 (Mouse) by D. Ouellette
Sox15 (Mouse) by  T. Tavares
Sox17 (zebrafish) by M. Xu
Sox21 (Chicken) by C. Sok
Squint/nodal (zebrafish) by J. Charlebois
srf - Dictyostelium discoideum serum response factor (Dictyostelium discoideum - slime mold) by E. Squires
SRY (Human) by R. Poulter
Tau (Microtubule-Associated Protein Tau - MAPT- Human) by O. Halitsky
Tbx1 (mouse) by R. Lai
Tbx3 (chick) by M. Burdzy
TBX3 (Human) by A. Nakrawala
Tbx4, and Tbx5 (Chick) by E. Tsakalis and T. McWilliams
Tbx5 (mouse) by S. Khiev, and T. Mcwilliams for a more elaborate site
Tbx5(Human) by D.Papadimitriou & B. Leventis
Tbx5 (Xenopus) by M. Hillman
Tbx 6 (Mouse) by by N. Koushik
Tbx15 (mouse) by F. Lutfallah and N. Henderson
Tbx20 (comaparison of different animals) by L. Siara
TDGF (Teratocarcinoma-Derived Growth Factor - Mouse) by R. Tousignant
Tes (Testin, Xenopus) by J. Charlebois
TGF-beta Tranforming Growth Factor (Chick) by J. Relic
Telomerase (Human and Mouse) by T. Wood, A. Pavlov, and A, Adefowara
TGIF (human TALE homeodomain and holoprosencephaly) by S. Davis
Thyroid Receptor (TR, c-erb) (Mouse) by G. Henel & Cheryl Richards
Tip 60 a myst Histone Acetyl transferase) (mouse) by S. Petrinac
toy - twin of eyeless  (Drosophila) by E. McCormick see also the homolgues see Pax6 (human homologue) and eyeless (Drosophila)
Troponin - Cardiac troponin I (Xenopus) by B. Hunter
Trp63 by B. O'Neil
Tsh (teashirt - Drosophila) by T. Huynh (modified)
Tsixantisense to Xist (mouse) by J. Saso
Vasa (Drosophila) by K. Asubonteng
Vax2 (Mouse) by L. Palombo
VegT (Frog- Xenopus) by S. Di Pietro
Wingless (Drosophila) by G. K. Randhawa
Wnt1 (wingless homolog)(Xenopus laevis) by C. Rixon and Wnt1 (in chick) by I. Voltic
Wnt3, Ephrins, Ryk and neural patterning (Chick) by N. Samaan
Wnt3a (mouse) by H. Gison, A. Alphonsas and P. Maarbes
Wnt-7a (wingless homolog) (Mouse) by N. Abdul-Kader& A. Sheehan
Wnt8b (various) by T. Frigon
Wnt8 (Zebrafish) by R. Poulter
Wnt10 ((chick) by B. Tomsich
Wnt-11  (Xenopus) by S. Thangavel
Xnr3 (xenopus nodal-like TGF beta secreted factor) by C. Dakhil
Xist (Mouse, Human) X-Inactivating transcript by V. Pardalis
Zic 1, 2, 3 (Mouse) by W. Al-Sinjakli and Zic3 (mouse) specifically with regard to laterality by J. Riley
Zic5 (mouse) by R. Zora
Zm Rpd3 (a Histone Deacetylase - HDAC) (Zea mays) by C. Chen


Other Interesting Phenomena
 

Alzheimer's as prion disorder?  by Sylvie Tremblay
Amyloid Protein (Alzheimer's as prion disrder) by Sylvie Tremblay
Angiospeerm gametophyte evolution by S. Jamal
Chromocenter formation (Drosophila) by R. Macera
Cloning Ethics and Stem Cell Sources (Human) by S. Newcomb
Cloning Mammals (Mouse) by G. Timis
Copy number variation and human evolution by S. Kipping
Dorsal signalling by Nodal/squint (zebrafish) by J. Charlebois
Epigenetics in: Paramutation (in cKit - mouse), mutation reversion (Arabidopsis Hothead gene)
Laterality and H+ K+ Pump  by S. Squire
Limb Evolution: role of Hox Genes by C. Luu
Limb Evolution: Fin to Limb Transition (molecular evolution) by M. Franczak
Limb Evolution: Fin to Limb Transition (paleontology) by A. Lumani
Micro RNA and RNAi see let7 by A. Van Delinder, Dicer (dcr-1) by E. Harrison, and miRNA by B. Bogucki
Neanderthal genome sequencing by W. Tashakor
Otx2 - a more full-featured link by J. Borbely
Paramutation (mouse cKit gene phenotypes)
Paedomorphy and evolution (Dinosaur Massospondylus) by C. Bleau
Spemann's Organizer - a more full-featured link by H. Cheah
Stem Cells - Alternative Sources (human) by G. Dakhil
Stem Cell Sources and Cdx2 (Human) by S. Newcomb
X-inactivation and Calico Cats by W. McCormick



Interesting Human Mutations

Alzheimer's as prion disorder?  by Sylvie Tremblay
Adenosine deaminase see SCID (Severe Combined Immunodeficiency) by T. Wood
AMH (Anti Mullerian Hormone and Receptor - cryptic hermaphrodism) by E. Kirou
Amyloid Protein (Alzheimer's as prion disrder) by Sylvie Tremblay
Atrx (alpha thalassemia - short description of effect on globin genes) or ATRX by K. McDowell
Arx  Aristaless-like homeobox (human) by J. Plumb
cancer-causing translocation hotspots  (hematopoeisis) by S. Petrinac, also see SGS1 Helicase (Werner's Syndrome) by K. Thickett and chromosome stabilty factor ATRX by K. McDowell
connexin-26 (Deafness) by M. Sharon
Copy number variation and human evolution by S. Kipping
CREBBP (CREB Binding Protein) (Human) by N. Raihan
DLL3 (human and mouse) by S. Perko
DM Kinase (Myotonic muscular dystrophy and triplet expansion syndromes)
DNMT 3B (DNA Methyltransferase 3B - Human) by E. Kalmantis
Dynein (Kartanager Syndrome) by C. Beaumont
FGF8 (human) by J. Grando
FGFR2 (Human FGF receptor 2) by E. Montcalm
Filamin A (various actin and transcription factor modulated syndroms) by M. Duronio
FGF10 (Human) by K. Neal and S. Warriach
FMR1 (Fragile X Syndrome) Human) by S. Perko
Ftz1 a.k.a. Nr5A1 (Human Sex Reversal with Gonadal agenesis and  adrenal insufficiency) by J. Simmons
Foxp2 (Human) by J. Zazula and C.J. Agres
H19 (human) by M. St. Pierre
Hemoglobin -Fetal disorder (HFHD)  (Human) by N. Jun
Helicase SGS1 (Werner's Syndrome) by K. Thickett
HOXA1 (humna) by M Reis et al..
HOXD10 (Charcot-Marie Tooth Syndrome) by M. Madra
HOXD13 (Synpolydactyly) by L. Berthiaume
HPRT1 (Lesch-Nyhan syndrome) by L. Bauer
Human Evolution - copy number variation  by S. Kipping
Human Evolution - Neanderthal Sequencing by W. Tashakor
Integrin b-1 and Hirschsprung disease (human) by P. Rizk
KRIT1 (Cerebral Cavernous Malformation) by J. Saso
KRIT1 (Cerebral Cavernous Malformation) by J. Martin
LINES (retrotransposn insertion) by R. Tousignant
MAPT (Microtubule-Associated Protein Tau - Human) by O. Halitsky
MECP2 (Rett Syndrome and chromatin packing) by P. Maarbess
MesP2 (Notch pathway)
miRNA (Control of development through Hox genes) by K. Myslik
MSX1 by J. Skiba
Neanderthal genome sequencing by W. Tashakor
Neuroligins (NLGN3 & 4, autism, Asperger's Syndrome) by I. Baran
Nr5A1 a.k.a. Ftz F1 (Human Sex Reversal with Gonadal agenesis and  adrenal insufficiency) by J. Simmons
Pancreas and SHH specification by S. Stanic
Pitx2 (Rieger's Syndrome) by L. Siara
SALL4 (Okihiro Syndrome) by S. Hills
SGS1 Helicase (Werner's Syndrome) by K. Thickett
Sonic Hedgehog (SHH, holoprosencephaly, Human) by S. Palombo
SRY (Human - gender mis-assignment) by R. Poulter
TBX1 (DiGeorge Syndrome) by D. Papdimitriou
TBX3 (Human) by A. Nakrawala
Tbx5(Human) by D.Papadimitriou & B. Leventis
TCOF (treacle - Treacher Collins Francisichetti Syndrome) by K. Quinn
TGIF (human TALE homeodomain and holoprosencephaly) by S. Davis
Transposons (LINES) by R. Tousignant
SCID(Severe Combined Immunodeficiency) by T. Wood
SHH and pancreas specification by S. Stanic
Sox9 (Human) by A. Shah
Tau (Microtubule-Associated Protein Tau - MAPT- Human) by O. Halitsky



Molecular Techniques Descriptions

Polar Body Biopsy (Human) by J. Martin
Stem Cells - Alternative Sources (human) by G. Dakhil
Stem Cell Sources and Cdx2 (Human) by S. Newcomb
 


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