55-355 Embryology
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Syllabus
WOLPERT: Principles of Development:Page
Number in 5th Edition
GILBERT: Developmental Biology:
Page Number 10th Edition
Page Number 9th Edition
Page Number 8th Edition
1) Introduction to course structure and grading.
p
105, 630
- Evolution
meets Development - introducing the phylotype
-
Phylostratigraphy
p 15-17
- Agenda for our
studies
2) Pattern
Formation
p
27-9, 295-300, 595, 598 608-9
-
Gradients
and Morphogens
p
113-115, 499
-
Monotonic
Gradient
p
116-118
-
Wolpert's
French Flag
Model
p 21-22, 63-6
-
Bryant's
Polar Co-ordinate Model
-
Example of flowering plants
3) Brief outline of the Beginnings/Questions of Embryology
p
325-30, 332-3, 336-7, 339-43, 347-50
- Stem
Cells, Differentiation, and
Potential
p 319-329
-
Epigenesis
Preformationism - animalculists vs ovists p
323-327, 623-624, 12-14, 122
-
Spontaneous
Generation
p 6-7, 66-7, 176, 489-90, 157, 683-9
4) Gametogenesis
p
416-19, 424-6
-
Meiosis
p 117-123
-
Spermatogenesis
p 122-126
-
Oogenesis
p 175-95, 199-205
5)
Fertilization
p
426-9
-
Capacitation
p 123-147
-
Chemotaxis
p 126-139,
148-153
-
Fusion
p 175-95, 199-205
-
Blocks to polyspermy
-
Syngamy
6) Imprinting
p 420-3
-
Genetic non-equivalence of germ cells
p 148
-
Methylation
p 154-155
-
Acetylation of
histones
p 207, 117-8, 101-2
-
Possible evolutionary benefits
7) Cleavage
p
369-76, 383, 386-88, 112, 158-59
-
Patterns of
cleavage
p 157-163, 170-171, 180-182, 217-221,
241-245, 271-275, 286-287
-
Compaction
p 159-163, 165-166, 192-194, 204-205,
241-245
-
Epiboly
p 211, 214-5, 217, 230-1, 243-4, 253-5, 291-4,
325-31, 336-8, 348-50
-
Mid-blastula
transition
8) Cell Sorting- Cellular Basis of
Morphogenesis
p 254-64, 603-6
-
Cell
death
p 70-79, 218-220,550-551
-
Differential
growth
p 167-169, 564-566
-
Adhesion
p 67-73, 217-219
-
Cell shape change
-
Cell migration
-
Regeneration applications
9)
Gastrulation
p
377-92, 164-72, 199-205
-
Germ layers - ectoderm, mesoderm,
endoderm
p 158, 160, 183-185,
191-192, 225-232, 245-251, 275-277, 287-293
-
Organizer - Hensen's node, dorsal
lip
p 172-175, 206-208, 242, 246-251,
255-256, 257-258, 260-266, 275-280,
290-296
-
Activation
Transformation
p 223-8, 256-8, 295-301, 329-31, 339-42, 354
10) Induction, Competence, Specification,
Determination
p
235-38, 24-7
-
Mosaic vs regulative
development
p 109-110
-
Commitment - specification vs
determination
p 253-255
-
Induction Conservation of inductive (genetic) pathways
p 316-9, 137,144-6
11) Dorso-Ventral Axis
Determination
p
51-3, 61-4, 149-52, 173-4, 392-4
-
Frog compared to
fly
p 242, 266, 314-315
-
Neural
plate
p 215-217, 266-267,
-
Neural
Tube
p 265, 306-11, 317, 331-5, 384-5
-
Neural Crest and axial mesoderm
-
Dorsal Ventral Patterning: St. Hilaire Revisited
12) Developmental Genetics Drosophila - Mammal
p 39, 44-53, 55, 91-5, 632-35
-
Maternal effect genes
- Gap
genes
p 180-189, 195-213, 311-314, 695-697
-
Segmentation
genes
p
208-211, 218-235, 314-317
-
Segment selector
genes
p 258-60, 266-287, 361-4
-
Mouse - Hox genes co-linearity
-
Evolutionary implications of Hox gene structure/activity
-
Problems with the paradigm
-
Dawkin's Selfish Gene Hypothesis Revisited
13) Head Organizer and
Segmentation
p
167-72, 522-31
-
Retinoic acid
effects
p 341-345
-
Zebrafish
organizer
p 341-345
-
Prosomere
model
p 319-22
-
Hindbrain and Hox genes
-
miRNA and Brain Development
14) Sex Determination
I
p
430-35
-
Gonad
development
p 520-530
-
Wolffian vs Mullerian
ducts
p 523-533, 536-538
-
Chromosomal basis for sex
determination
p 529-40, 550-2
-
Hormonal basis for sex determination Source of germ cells
15) Sex Determination II
p
430-40
- Sry
and Xist
Dax
p 520-530
-
Dosage
compensation
p 512-513, 534-538, 664-665
-
X-inactivation
p 529-40, 550-2, 119-124
16) Limb
development
p 447-9, 452-4, 635-43
-
Source of
cells
p 489-514
-
Mesonephic
mesenchyme
p 495-509
-
Apical ectodermal
ridge
p 505--24
-
Progress zone
-
Zone of polarizing activity
-
Retinoic acid
-
Gene regulation
- Hox
code
-
Metapterigial arch
-
Problems - regeneration gene expression patterns
17) Heart
Development
p
504-7
-
Chick compared to
Frog
p 450-455
-
Tube and
folding
p 446-450, 317-319
-
Retinoic acid
effects
p 472-9
-
Tinman/Nkx genes
-
GATA factors
-
Capillary formation
-
Assymetry and genetic regulation
18) Eye Development and Lens Induction (competence and induction
revisited)
p 489-94
-
Placode formation /
induction
p 359-365
- Pax
genes and conservation of eye developmental pathways p
79-82, 359-365 p 140-3, 397-401
19) Developmental Strategies for Exploiting
Environments
-
Complex developmental
pathways
p 549-560, 676-679
-
Dictyostelium
p 673-675, 542-550
-
Cnidarians
-
Metamorphosis - flies Frogs and newts
-
Amphibian metamorphosis and thyroid hormones
-
Direct development
-
Neoteny
20) Development and
Evolution
-
Ontogeny and phylogeny
revisited
-
Epigenetic
considerations
p 708-712
-
Spandrels of San Marco
| Assignments
| Dr.
Crawford's
Homepage | 355
Homepage |