Dept. Biological Sciences
University of Windsor
lab: (519) 253-4232 ext. 2721
(519) 971- 3609
During early embryogenesis cells differentiate into
the right cell type, in the right place, and at the right time.
How this process is regulated, how a body map or plan is established is
still poorly understood. A class of genes, called homeobox
genes, which encode DNA-binding proteins are thought to play a role in
setting a developmental agenda. The products of these genes bind
to other genes and regulate their activity. In a sense they can
be thought of as master control switches for developmental programs.
interests have focused upon problems relating to head, face, and heart
development. In the lab, we have been manipulating frog embryos to
study the role of these genes in this process. In particular, we
have been trying to elucidate the effects of gain and loss of function
of Pitx gene family members in an effort to define the role that they
play during craniofacial modeling. We have completed a microarray
survey and have identified potential down stream targets of Pitx3 in
the pathways that regulate eye, somite, heart and gut. Other projects
we will be pursuing involve: the role of these and related genes during
limb development, regulation, and regeneration; the role of retinoids
in the regulation of pattern formation; and the role of Cyclase
Associated Proteins (CAP1 and CAP2) in early development.