Immunology Course Manual
03-55-242-91
TABLE OF CONTENTS
Immunology is an exciting and challenging field with theoretical and practical applications. For many students, the challenge of immunology can be intimidating yet it need not be. Like many areas in biology it builds steadily from simple beginnings. If you learn not only the facts, vocabulary and concepts of immunology, but also master the problem solving process, you will be able to apply these ideas to new problems. This is the true adventure of immunology;
“To boldly go where no one has gone before.”
Mastery of the problem solving process improves with practice. While the facts and vocabulary of immunology can be learned in a few “all-nighters”, mastery of the concepts and processes takes time, so start early. This one semester course cannot cover this entire field completely, but hopefully it will trigger an interest to pursue further studies in more advanced immunology courses.
“Go Forth and Prosper”
We strongly recommend that you have taken the following courses: 55-140, 55-141 or their equivalent. Contact your instructor if you have any questions.
The course co-requisite is 59-230.
This course consists of study of antibody formation, the structure of antibodies and antigens and the mechanisms of antigen-antibody interactions.
The above, is an “official” description of the Immunology Course as you can find in the Undergraduate Calendar and obviously a very narrow one. The immune system is complex, and immunologists have employed a complex terminology to describe it. While developing this course we have taken great pains to minimize the problem that this terminology can pose for non-immunologists. We have defined all terms when they are introduced and avoided jargon or unnecessary abbreviations. The emphasis on problem solving is a particularly valuable feature of our course since you may find this skill very useful in more advanced science courses. With the enormous scope of the subject and the extraordinary richness of detail available, we have made every effort to address immunology in a meaningful way and provide accurate and timely information.
Once you have successfully completed this course you will develop
Specifics of the course content follow the textbook Immunology 4rd edition, by Janis Kuby. The topic outline provides sufficient detail of major concepts to be covered along with a weekly schedule.
| Schedule of Topics and Assignments | |||||
| LESSON | Topic | Title | |||
| 1 | 1 | Overview of the Immune System | |||
| 2 | Cells and Organs of the Immune System | ||||
| 2 | 3 | Antigens | |||
| 4 | Immunoglobulins: Structure and Function | ||||
| 3 | 5 | Antigen-Antibody Interactions | |||
| 6 | Organization and Expression of Immunoglobulin Genes | ||||
| 4 | 7 | B-Cell Maturation, Activation, and Differentiation | |||
| 8 | |||||
| 5 | 9 | ||||
| 10 | T-Cell Receptor | ||||
| 6 | 11 | T-Cell Maturation, Activation, and Differentiation | |||
| 12 | Cytokines | ||||
| 7 | 13 | The Complement System | |||
| 14 | Leukocyte Migration and Inflammation | ||||
| 8 | 15 | Cell-Mediated and Humoral Effector Responses | |||
| 16 | Hypersensitive Reactions | ||||
| 9 | 17 | Vaccines | |||
| 18 | Immune Response to Infectious Diseases | ||||
| 10 | 19 | Autoimmunity | |||
| 20 | The Immune System in AIDS | ||||
| 11 | 22 | Transplantation Immunology | |||
| 22 | Cancer and Immune System | ||||
| Final Practice Exam | |||||
L.
You
should purchase the following materials from the University Bookstore, phone:
1-800-263-1242 or 519-253-3000 x3476, fax: 519-973-7038, online ordering: http://www.bookstore.uwindsor.ca.
textbook: Immunology, 4rd
edition by Janis Kuby
Print Guide: Immunology,
Maria Sawicki and Hugh Fackrell.
The
textbook has a Web site that we recommend you spend some time browsing through.
You may benefit from this site by viewing how immunology affects our lives on a
day to day basis. See the Textbook Key for more detailed information.
n
data with Rasmol software program for
assignment completion. See the Instructor and Assignment Information for
details.
How to study Immunology
Instructor and Assignment Information
Through
mail, e-mail or the Web, your instructor will provide you with information on
how to reach him or her, your assignments,
and grading. If you have not
received this information from your instructor by the semester start, contact
SIRC at 519-561-1414 or askme@uwindsor.ca
Your
instructor, who is an expert in Immunology, should be contacted for any
assistance that you require related to the content of this course.
You should contact your instructor with any questions related to:
course prerequisites
course subject matter
exercises
assignments
sample solutions
duration and format of the final exam
final grades.
Remember
that you are responsible for the cost of all telephone calls.
Assignments and the Final Exam
Your
grade in this course will be based upon assignments and a final examination, the
time and location of which will be scheduled by the Office of the Registrar.
Your instructor will provide information on instructor assistance, assignments,
grading, the midterm examination (if applicable) and the format of the final
examination. For information on the locations and dates of final examinations,
please visit www.uwindsor.ca/flexible.
When
you receive the assignment solutions you should review them carefully, comparing
them to the answers which you submitted. Remember
to keep a copy of all assignments you submit.
Grading
Questions about Distance Education
Contact
the Student Information Resource Centre (SIRC), which can provide answers to
most student questions.
SIRC
University of Windsor
Windsor, Ontario N9B 3P4
519-561-1414 * Fax: 519-971-3623 * askme@uwindsor.ca
Hours: M-Th 8:30am - 7pm * Fri 8:30am - 4:30pm EST
Location: Ground-level floor, CAW Student Centre
Online Support for Distance Students
The
University of Windsor has several sites linked to its home page (http://www.uwindsor.ca)
that may prove helpful to you:
The Student Self Service is an Office of
the Registrar site that allows you to confirm your registration and to
request degree audits, grade reports or transcripts, among other things.
The Leddy Library site provides access to
various public and university library catalogues, databases, electronic
journals, and tutorials on using the Internet.
Programs of Study will lead you to
information about the various academic departments, programs and faculty
members.
Calendars & Admissions is linked to
online versions of the university's undergraduate and graduate calendars.
New & Coming Events will keep you up to
date on university happenings.
For more information about Flexible Leaning at the University of
Windsor, please visit www.uwindsor.ca/flexible.
In
addition, you might find the following sites to be helpful:
|
•
the
NODE |
• Use NODE’s Learner Resources |
|
• The reference shelf •
Online
reference sources for basic research |
• The study buddy •
Help
with time management, study strategies and essay-writing |
|
• The virtual librarian •
How
to find, evaluate, and use electronic information |
• The technology toolkit •
The
basics of Internet tools: e-mail, ftp, telnet, etc. |
Biography of Course Developers
The course material is organized into 11 lessons, which in turn are composed of a total of 22 topics. You will find that the material in some topics is less challenging than in others. You should be able to proceed fairly quickly through this material, allocating more time to the more challenging material that follows.
The textbook for this course is Immunology by Janis Kuby, 3rd edition, (New York, W.H. Freeman and Co.) 1997.
The textbook also has a Web site where you can link to images, movies and animations of cells undergoing an immune response as well as view three dimensional representations of molecules.
You may benefit from this site by viewing how immunology affects our lives on a day to day basis. The address is: http://whfreeman.com/immunology
The following is a list of the chapters that you are required to read for each lesson. I recommend that you briefly look over the lesson notes paying particular attention to the objectives then read the corresponding chapter. This process gives you a focus for what to concentrate on in the textbook. Then go back and carefully read the lesson notes. I recommend that you keep this Key where you will have easy access to it.
Lesson 1
Topic 1
Assigned Reading: Chapter 1, pages 3-22
Topic Summary: page 22
Assigned Study Questions: pages 22-23
Topic 2
Assigned Reading: Chapter 3, pages 47-80
Topic Summary: page 80
Assigned Study Questions: pages 82-83
Lesson 2
Topic
3
Assigned Reading: Chapter 4, pages 87-104
Topic Summary: page 104
Assigned Study Questions: pages 105-106
Topic 4
Assigned Reading: Chapter 5, pages 107-139
Topic Summary: page 139
Assigned Study Questions: pages 140-142
Lesson 3
Topic
5
Assigned Reading: Chapter 6, pages 143-162
Topic Summary: page 162
Assigned Study Questions: pages 162-164
Topic 6
Assigned Reading: Chapter 7, pages 165-190
Topic Summary: page 190-191
Assigned Study Questions: pages 192-193
Lesson 4
Topic
7
Assigned Reading: Chapter 8, pages 195-218
Topic Summary: page 219-220
Assigned Study Questions: pages 221-222
Topic 8
Assigned Reading: Chapter 9, pages 223-245
Topic Summary: page 245-246
Assigned Study Questions: pages 246-248
Lesson 5
Topic
9
Assigned Reading: Chapter 10, pages 249-260
Topic Summary: page 260
Assigned Study Questions: pages 261-262
Topic 10
Assigned Reading: Chapter 11, pages 263-281
Topic Summary: page 281-282
Assigned Study Questions: pages 282-283
Lesson 6
Topic
11
Assigned Reading: Chapter 12, pages 285-307
Topic Summary: pages 307-308
Assigned Study Questions: pages 309-310
Topic 12
Assigned Reading: Chapter 13, pages 312-332
Topic Summary: pages 332-333
Assigned Study Questions: pages 333-334
Lesson 7
Topic
13
Assigned Reading: Chapter 14, pages 335-354
Topic Summary: pages 354-355
Assigned Study Questions: pages 355-356
Topic 14
Assigned Reading: Chapter 15, pages 357-376
Topic Summary: pages 376-377
Assigned Study Questions: pages 378
Lesson 8
Topic
15
Assigned Reading: Chapter 16, pages 379-408
Topic Summary: pages 408- 409
Assigned Study Questions: pages 410-411
Topic 16
Assigned Reading: Chapter 17, pages 414-436
Topic Summary: pages 437- 438
Assigned Study Questions: pages 438-439
Lesson 9
Topic
17
Assigned Reading: Chapter 18, pages 443-456
Topic Summary: page 456-457
Assigned Study Questions: pages 457-458
Topic 18
Assigned Reading: Chapter 20, pages 485-503
Topic Summary: page 503
Assigned Study Questions: page 504
Lesson 10
Topic
19
Assigned Reading: Chapter 21, pages 507-519
Topic Summary: page 519-520
Assigned Study Questions: pages 520-521
Topic 20
Assigned Reading: Chapter 22, pages 523-552
Topic Summary: page 552
Assigned Study Questions: pages 553-554
Lesson 11
Topic
21
Assigned Reading: Chapter 23, pages 555-570
Topic Summary: page 570
Assigned Study Questions: pages 571-572
Topic 22
Assigned Reading: Chapter 24 , pages 573-594
Topic Summary: page 594-595
Assigned Study Questions: pages 595-596