Chapter 4:
Acquired Epigenetic Changes - Dietary Influences upon Health and
Longevity
- Starvation
- Over-feeding
- Seasonal changes
- Dietary availability (geography)
- Medical conditions - Crohn's, diabetes, coeliac, eating disorders
etc.
Reading:
R.C. Painter, et al. Prenatal exposure to the Dutch famine and disease
in later life: an overview.
Reprod Toxicol
2005; 20: 345-352.
L.H. Lumey, et al. Lipid profiles in middle-aged men and women after
famine exposure during gestation: the Dutch Hunger Winter Families
Study. Am J Clin Nutr 2009; 89: 1737-1743.
Chapter 5: Trans-Generational Effects -
Dietary Influences
- Starvation
- Overfeeding
- Some examples yet to be mined: Chinese and N. Korean famines,
Michael Bloomberg's New York experiment,
Reading:
L.O. Bygren, et al. Longevity determined by paternal ancestors'
nutrition during their slow growth period. Acta Biotheor 2001; 49:
53-59.
R.C. Painter, et al. Transgenerational effects of prenatal
exposure to the Dutch famine on neonatal adiposity and health in later
life. BJOG 2008; 115: 1243-1249.
Chapter 6: Social influences Upon
Epigenetic States
- Nuturing
- Abuse, depression, and stress (PTSD?)
- Socio-economic status
- Education
- Exercise and the Built Environment
- Cultural, geographical, and racial factors
Reading:
D. McGuinness, et al. Socio-economic status is associated with
epigenetic differences in the pSoBid cohort. Int J Epidemiol 2012; 41:
151-160.
I.C. Weaver, et al. Epigenetic programming by maternal behavior. Nat
Neurosci 2004; 7: 847-854.
B.G. Dias & K.J. Ressler. Parental olfactory experience influences
behavior and neural structure in subsequent generations. Nat Neurosci
2014; 17: 86-96. (Pick this up as a copy from the Biology Main Office)
Privacy
F.F. Costa. Big data in biomedicine. Drug Discov Today 2013. (you have
this in your folder of PDFs)
Chapter 7: Epigeneic Risks and Medicine
- IVF
- Drugs (verapamil, DES)
- Epigenetics and Cancer
- Remediation: Finnish "Baby Box" program, Hawaii
Reading:
R.R. Newbold, et al. Adverse effects of the model environmental estrogen
diethylstilbestrol are transmitted to subsequent generations.
Endocrinology 2006; 147: S11-17.
M.H. Johnson. The problematic in-vitro embryo in the age of epigenetics.
Reprod Biomed Online 2005; 10 Suppl 1: 88-96.
Chapter 8: Environmental Epigenetics and Risk
Assessment/Remediation
- Estrogen mimics (BPA, etc)
- Heavy metals (not Van Halen, Metallica etc)
- Insurance and Litigation
Reading:
D. Ziech, et al. The role of epigenetics in environmental and
occupational carcinogenesis. Chem Biol Interact 2010; 188: 340-349.
B. Mansfield. Race and the new epigenetic biopolitics of environmental
health. Biosocieties 2012; 7: 353-372.
Chapter 9: Epigenetics: The Ethical, Legal, and Regulatory
Challenges
Reading:
M.A. Rothstein, et al. The ghost in our
genes: legal and ethical implications of epigenetics. Health Matrix
Clevel 2009; 19: 1-62. (Read
pp 16-22)
C. Dupras, et al. Epigenetics and the Environment in Bioethics.
Bioethics 2012.
Chapter 10: Epigenetics and Privacy
Considerations
- Access to medical records
- Insurance, Social Planning
- Inferences from collected and mined data (Google, Amazon, NSA)
- communication history/associations
- purchasing history
- geographical history
- income history
- educational history
- browser history
- gaming history
- patterns of cloud use
Reading:
S.D. Kahn. On the future of genomic data. Science. 2011. 331: 728-729
(If connected on campus or through the Leddy, this paper is accessible
through this link: http://www.sciencemag.org/content/331/6018/728.full)
M.A. Rothstein, et al. Ethical implications of epigenetics research. Nat
Rev Genet 2009; 10: 224.