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4.3.1 COURSE DESCRIPTIONS
All of the courses listed will not necessarily be offered in any one
year. Topics courses may be taken several times provided the course content
is different. Where prerequisites are not stated, consent of the instructor
is required.
59-521. Special Topics in Analytical Chemistry
(Prerequisite: 59-321.) (2 lecture hours a week.)
59-531. Special Topics In Organic Chemistry
Topics may include polymer chemistry, natural product chemistry, physical
organic chemistry, or design and execution of organic syntheses. (Prerequisite:
59-331 or consent of instructor.) (2 lecture hours a week.)
59-535. Advanced Organic Chemistry
Physical organic chemistry. Includes molecular orbital theory, stereochemistry,
thermodynamics, and reaction mechanisms. (Prerequisite: consent of instructor.)
(2 lecture hours a week.)
59-541. Statistical Thermodynamics
Development of statistical thermodynamics and its application to theories
of gases, condensed states, and chemical equilibria. (2 lecture hours a
week.)
59-542. Fourier Transform Nuclear Magnetic Resonance Spectroscopy
Theory and applications of FT NMR in chemical problems, special techniques
such as T1, T2 measurements, cross polarization, "magic angle" spinning,
2D spectroscopy, DEPT pulse sequences, and others will be covered. (2 lecture
hours a week.)
59-545. Special Topics in Physical Chemistry
(2 lecture hours a week.)
59-546. Advanced Topics in Spectroscopy
Electronic and vibrational spectroscopy of gases, liquids, and solids.
Theory and practice of infrared and Raman spectroscopy. Theory and applications
of electron spin resonance spectroscopy. (2 lecture hours a week.)
59-550. Applications of Group Theory
Various applications of group theory to the study of organic, inorganic,
and organometallic systems. (3 lecture hours a week.)
59-552. Topics in Inorganic Chemistry and Organometallic Chemistry
Topics to be arranged by the instructor, based primarily upon new developments
in the field as illustrated by the current research interests of the faculty,
as well as by a study of the current literature. (2 lecture hours a week.)
59-553. X-ray Crystallography
Theoretical and experimental aspects of single crystal X-ray diffraction
methods for the determination of molecular structures. (2 lecture hours
a week.)
59-564. DNA Science and Diagnostics
An advanced lecture and laboratory course dealing with DNA science
and the application of DNA technology in the understanding and diagnosis
of human disease. The lectures cover the biochemistry and expression of
DNA and RNA at the molecular level, the theory and practice of recombinant
DNA technology and the application of DNA probes in the diagnosis of human
disease. The laboratory component involves construction and cloning of
a recombinant DNA molecule. (Prerequisites: 59-360, 59-361, and 59-365,
or consent of instructor; antirequisite: 59-468.) (2 lecture hours, 1 laboratory
hour a week.)
59-565. Membrane Biochemistry
The structure and function of artificial and natural membranes. Special
consideration will be given to the identification and function of membrane
proteins. (Prerequisites: 59-360 and 59-361 or 59-362 and 59-363, or equivalent.)
(2 lecture hours a week.)
59-570. Advanced Quantum Chemistry
Perturbation and variation theories. Theories of many electron atoms
and general theories of chemical bonds in diatomic and polyatomic molecules.
(Prerequisite: 59-341 or equivalent.) (3 lecture hours a week.)
59-581. Analytical Toxicology
Analysis of drugs and other toxic substances in biological fluids.
The metabolism of drugs as well as the symptomology of poisoning of common
therapeutic drugs and the more common industrial chemicals will be discussed.
(Prerequisites: 59-360 and 59-361 or 59-362 and 59-363, or consent of instructor.)
(2 lecture hours a week.)
59-589. Clinical Chemistry Laboratory Methodology
A detailed study of the existing clinical chemistry laboratory procedures.
Seminars, papers, and field trips will be required. (Minimum 500 hours.)
59-600. Directed Special Studies
A special course of studies with content and direction approved by
the student's research advisor and supervisory committee. Although there
may be no formal lecture requirements, the course will be equivalent to
three one-hour lectures a week for one term. The student will be required
(a) to produce a critical review which will be assessed by his or her supervisory
committee; the presentation and standard of the review must be appropriate
for publication in a scientific journal; (b) to spend one term working
in an agreed industrial setting; the quality of work will be assessed by
the supervisory committee. This work may be related to but not part of
the research undertaken in 59-797 or 59-798. (Prerequisite: approval of
the Program Committee.)
The course cannot be repeated for credit under (a) above. Under normal
circumstances, M.Sc. students may take this course only once; Ph.D. students
may register under (b) above for two terms of this industrial experience.
59-620. Analytical Spectroscopy of Surfaces
Surface spectroscopic techniques and their application to the analysis
of chemisorbed and physisorbed species and monomolecular layers. (Prerequisite:
59-321 or equivalent.) (2 lecture hours a week.)
59-630. Synthetic Methods in Organic Chemistry
A study of some important organic reactions with emphasis on their
practical application in synthesis. (Prerequisites: 59-330 and 59-331,
or consent of instructor.) (2 lecture hours a week.)
59-631. Advanced Topics in Organic Syntheses
The design, execution, and methodology of total syntheses of complex
molecules will be discussed. Emphasis will be placed on both retrosynthetic
pathways and execution. (Prerequisites: 59-330 and 59-331, or consent of
instructor.) (2 lecture hours a week.)
59-633. Current Topics in Organic Chemistry
Topics to be arranged by the instructor, based primarily upon new developments
in the field as illustrated by the current research interests of the faculty,
as well as by a study of the current literature. (Prerequisites: 59-331
or consent of instructor.) (2 lecture hours a week.)
59-634. Advanced Topics in Organic Chemistry
Special topics in organic chemistry will be described. Some of these
may include natural product chemistry, organometallic chemistry or heterocyclic
chemistry. (Prerequisite: consent of instructor.) (2 lecture hours a week.)
59-636. Advanced Topics in Physical Organic Chemistry
A survey of structure, mechanism, and theory in organic chemistry.
(Prerequisite: consent of instructor.) (2 lecture hours a week.)
59-651. Organometallic Chemistry
A detailed study of selected advanced topics in organometallic chemistry.
Typical subjects include (at the discretion of the instructors) main group
organometallic chemistry; thermochemical methods in organometallic chemistry;
catalysis by organometallics, detailed structural studies. (2 or 3 lecture
hours a week.)
59-653. Advanced Topics in Organometallic Chemistry
Topics to be arranged by the instructor, based primarily upon new developments
in the field as illustrated by the current research interests of the faculty,
as well as by a study of the current literature. (2 lecture hours a week.)
59-655. Selected Topics in Inorganic Chemistry
Spectroscopic applications to inorganic systems. Typical of topics
covered from year to year are optical spectroscopy, vibrational spectroscopy
and normal coordinate analysis, ESR and NMR spectroscopy, and photoelectron
spectroscopy. (2 lecture hours a week.)
59-660. Protein Chemistry I
Protein chemistry; chemical modification, protein folding, post-translational
modification, lipoproteins, and glycoproteins. (Prerequisite: 59-365 or
equivalent.) (2 lecture hours a week.)
59-661. Protein Chemistry II
Biophysical chemistry; advanced kinetic techniques, pre-steady state,
perturbation based methods, review of instrumentation, and examples of
how these techniques are currently used to solve biochemical problems.
(Prerequisite: 59-660.) (2 lecture hours a week.)
59-663. Special Topics in Biochemistry
(Prerequisites: 59-360 and 59-361, or 59-362 and 59-363, or equivalent.)
(2 lecture hours a week.)
59-671. Special Topics in Theoretical Chemistry
Topics to be selected by registrants but will generally be molecular
orbital calculations for organic and inorganic chemists. (2 lecture hours
a week.)
59-680. Clinical Biochemistry I
An advanced lecture course dealing with the application of current
techniques in clinical chemistry in the diagnosis of human disease. The
various aspects of a clinical chemistry laboratory and its role in laboratory
medicine will be discussed as well as the new advances in the development
of clinical laboratory instrumentation.
59-681. Clinical Biochemistry II
The continuation of Clinical Biochemistry I. An advanced lecture course
dealing with the application of current techniques in clinical chemistry
in the diagnosis of human disease. The various aspects of a clinical chemistry
laboratory and its role in laboratory medicine will be discussed as well
as the new advances in the development of clinical laboratory instrumentation.
59-682. Biochemical Diagnosis of Human Disease I
An advanced lecture course dealing with the biochemistry of human disease,
including various aspects of physiological chemistry.The molecular and
biochemical basis of human disease will be discussed together with current
approaches to the laboratory diagnosis of human disease. The major human
organ systems will be discussed in terms of physiology, biochemistry, pathophysiology,
and laboratory investigation.
59-683. Biochemical Diagnosis of Human Disease II
The continuation of Biochemical Diagnosis of Human Disease I. An advanced
lecture course dealing with the biochemistry of human disease, including
various aspects of physiological chemistry.The molecular and biochemical
basis of human disease will be discussed together with current approaches
to the laboratory diagnosis of human disease. The major human organ systems
will be discussed in terms of physiology, biochemistry, pathophysiology,
and laboratory investigation.
59-684. Pathophysiology
Introductory course in human pathology with special emphasis on chemical
aspects of disease. An examination of the interrelationships and homeostatic
control of the major biochemical parameters in health, and the cause and
nature of the anomalies of these parameters occurring in disease. A case-oriented
approach to the diagnosis of disease based primarily on examination of
the biochemical parameters, with the aim not only of identifying the disease,
but also of explaining the significance of the pertinent biochemical parameters.
(Prerequisites: Biology 55-140 and 55-141, 59-360 or 59-362, or equivalent,
and consent of instructor.) (2 lecture hours a week and demonstrations.)
59-686. Advanced Bioanalytical Topics
(Prerequisite: 59-360 or 59-362, or equivalent.) (2 lecture hours a
week.)
59-689. Clinical Chemistry Research and Development
Original research and comparative studies leading to the development
of new clinical chemistry methods. Seminars and papers will be required.
(Prerequisite: 59-589.) (Minimum 500 hours.)
59-710. The Research Proposal
This course focuses on the development and presentation of a research
proposal, as well as the cultivation of a wide base of knowledge of the
chemical and biochemical literature. Techniques of research proposal composition,
with particular reference to subject area, budgetary considerations, and
written and oral presentation techniques will be discussed. The student
will be required to develop and defend his or her own research proposal
in chemistry and/or biochemistry. The subject of this proposal must not
be from the research work undertaken for the Ph.D. thesis. A written proposal
will be submitted to the student's advisory committee and will be followed
by an oral presentation and defense of the proposal. The advisory committee
will evaluate the originality, the significance, the clarity of the written
and oral presentation, and the student's knowledge of the area in the defense.
(Prerequisite: registration in the Ph.D. program. The oral presentation
and proposal defense will take place during the term of registration.)
59-795. Seminar
59-796. Major Clinical Chemistry Critique
59-797. Master's Thesis
59-798. Doctoral Dissertation
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