Practical Applications of Immunology

There are no dangerous thoughts; thinking itself is dangerous Hannah Arendt
	Until Next Time--- Adios Amoebas

Who am I? I developed the first effective vaccine against polio. This discovery alone saved many times more money than has ever been spent on medical research

WEB LINKS

The DNA Vaccine Web

The DNA Vaccine Web is hosted by the Centre National de la Recherche Scientifique, Paris, France. The site provides informaiton and additional links.

URL --> http://www.genweb.com/Dnavax/dnavax.html

Vaccine Advocates

This page is titled "Evolution of Vaccine Development." The site was prepared by the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

URL --> http://www.vactup.org/science/evolve.html

CDC Home Travel Information Page

CDC's Home Travel Information Page provides information on disease outbreaks, health recommendations, and reference materials.

URL --> http://www.cdc.gov/travel/travel.html

Vaccines: How They Work

Vaccines: How They Work is information from the Animal Pathology Laboratory at the Nova Scotia Department of Agriculture and Marketing. The piece deals with veterinary vaccines for those interested in veterinary medicine.

URL --> http://www.nsac.ns.ca/nsdam/pt/lives/furfacts/vaccines.htm

	Practical applications of Immunology
	ImmunoAssays in Microbiology
	Baron Medical Microbiology Chapter 1 Immunology Overview		Brock 9th Ed Biology of Microorganisms Chapt 20 Concepts of Immunology Chap 21: Clinical and Diagnostic Microbiology and Immunology
	Tortora: Microbiology An Introduction Chapt 18: Practical Applications of Immunology		Jacquelyn Black 4th Ed Microbiology: Principles & Explorations Chap 17: Immunology 1: Basic Principles
Presentation	Slides	Web Animation	Download
Practical Applications 1
Practical Applications 2
Complement

OUTLINE/SUMMARY

1. Active vs Passive Immunization
2. Vaccines for Active Immunization
3. Whole Organism Vaccines
4. Attentuated viral or bactrial vaccines
5. Inactivated viral or bactrial vaccines
6. Purified macromolecules as vaccines
   • polysaccharides
   • toxoids
   • Recombinant antigens
7. Recombinant Vector Vaccines
8. DNA Vaccines
9. Synthethetic Peptide Vaccines
10. Multivalent Subunit Vaccines
11. Anti-Idiotype Vaccines
12. Vaccines for Passive Immunization
    • Applications
    • Humanized antibodies

SHORT ANSWER QUESTIONS

1. Differentiate between variolation and vaccination.
2. Define vaccine. Name four types of vaccines and give examples of each.
3. Compare the acquisition passive and active immunization and give specific examples of each []
4. Discuss the recommended program for Childhood immunizations.[]
5. Construct a table to compare the advantages and disadvantages of attentuated vs inactivated vaccines.
6. compare the risks associated with attenturated or inactivated vaccines vs specific purified macromolecular vaccines.
7. Compare the three general forms of purified macromolecular vaccines; polysaccharide, toxoid, and recombinant antigens
8. Differentiate betweeen agglutination and precipitation tests.
9. Explain how a neutralization test works.
10. Explain the basis of the complement fixation test.
11. Explain how the direct and indirect ELISA tests work.
12. Explain the immunological basis of the home pregnancy test.
13. Explain the importance of monoclonal antibodies.
14. Draw a diagram to show the steps in the production of a vaccina virus vector vaccine[]
15. Draw a diagram to show the uses of an anti-idiotypeantibody as a vaccine.
16. Discuss the advantages of anti-idiotype vaccines[]
17. The World Health Organization has announced the complete eradication of smallpox and is working toward the eradication of measles and polio. Why would vaccination be more likely to eradicate a viral disease than a bacterial disease? Why is vaccination ineffective against AIDS?
18. What problems are associated with the use of attentuated whole-agent vaccines?