Vaccines

There are no dangerous thoughts; thinking itself is dangerous
Hannah Arendt

Who am I? I developed the first effective vaccine against polio. This discovery alone saved many times more money than has ever been spent on medical research

RESOURCES

The DNA Vaccine Web

The DNA Vaccine Web is hosted by the Centre National de la Recherche Scientifique, Paris, France. The site provides informaiton and additional links.

URL --> http://www.genweb.com/Dnavax/dnavax.html

Vaccine Advocates

This page is titled "Evolution of Vaccine Development." The site was prepared by the National Institute of Allergy and Infectious Diseases, National Institutes of Health.

URL --> http://www.vactup.org/science/evolve.html

CDC Home Travel Information Page

CDC's Home Travel Information Page provides information on disease outbreaks, health recommendations, and reference materials.

URL --> http://www.cdc.gov/travel/travel.html

Vaccines: How They Work

Vaccines: How They Work is information from the Animal Pathology Laboratory at the Nova Scotia Department of Agriculture and Marketing. The piece deals with veterinary vaccines for those interested in veterinary medicine.

URL --> http://www.nsac.ns.ca/nsdam/pt/lives/furfacts/vaccines.htm

ASSIGNED READING

CHAPTER 18: pp 443-458

OUTLINE/SUMMARY

1. Active vs Passive Immunization
2. Vaccines for Active Immunization
3. Whole Organism Vaccines
4. Attentuated viral or bactrial vaccines
5. Inactivated viral or bactrial vaccines
6. Purified macromolecules as vaccines
   • polysaccharides
   • toxoids
   • Recombinant antigens
7. Recombinant Vector Vaccines
8. DNA Vaccines
9. Synthethetic Peptide Vaccines
10. Multivalent Subunit Vaccines
11. Anti-Idiotype Vaccines
12. Vaccines for Passive Immunization
    • Applications
    • Humanized antibodies

PERFORMANCE OBJECTIVES

DEFINE THE FOLLOWING KEY TERMS:

ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:

1. Compare the acquisition passive and active immunization and give specific examples of each [444]
2. Discuss the recommended program for Childhood immunizations.[445]
3. Construct a table to compare the advantages and disadvantages of attentuated vs inactivated vaccines.
4. compare the risks associated with attenturated or inactivated vaccines vs specific purified macromolecular vaccines.
5. Compare the three general forms of purified macromolecular vaccines; polysaccharide, toxoid, and recombinant antigens
6. Draw a diagram to show the steps in the production of a vaccina virus vector vaccine[452]
7. Draw a diagram to show the uses of an anti-idiotypeantibody as a vaccine.
8. Discuss the advantages of anti-idiotype vaccines[455]
9. Compare solid matrix antibody-antigen complexes with immunostimulating complexes in the development of multivalent subunit vaccines. [455]

SHORT ANSWER QUESTIONS

1. Differentiate between variolation and vaccination.
2. Define vaccine. Name fouR types of vaccines and give examples of each.