Children have to be educated,
but they have also to be left to educate themselves
Ernest Dimnet
Who am I? I
demonstrated that antigens, when properly presented, induced some
lymphocytes to develop into plasma cells. I was the foirts to
formally demonstrate the one cell- one antibody rule
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| B Cell Maturation |
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- Cells
Alive!
- CELLS alive! is posted on the WWW as an educational
service of Quill Graphics. Below is a link to a location
at Cells Alive! that may be of general interest
URL
--> http://www.cellsalive.com/
Chap 8 pp 195-222
- B Cell Maturation
- Bone marrow
- Ig Gene rearrangements
- Pre B cell receptor
- Selection of Immature Self Reactive B Cells
- negative selection
- rescue editing of light chain genes
- B Cell Activation & Proliferation
- T dependent vs T independent antigens
- Origins of activating signals
- Transduction of Activating signals
- B cell coreceptor complex
- T helper cells
- formation of T-B conjugate
- mediation by CD40
- induction of progression signals
- Negative selection
- In Vivo induction of Humoral Response
- B Cell Differentation
- Affinity maturation
- somatic hypermutation
- antigen selection
- Class switching
- Plasma cells
- Memory cells
- Regulation of B Cell Development
| DEFINE
THE FOLLOWING KEY TERMS: |
| affinity maturation |
apoptosis |
avidity |
| capping |
carrier effect |
cell mediated immunity |
| Cytotoxic T cells |
Helper T cells |
TH1 cells |
| TH2 cells |
humoral immunity |
immunologic memory |
| perforin |
plasma cells |
primary antibody |
| programmed cell death |
secondary antibody |
thymus dependent antigens |
| thymus independent antigens |
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ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Describe the sequential development of the humoral immune
response.
- Draw a contemporary model for T cell B cell macrophage
interaction
- Describe antigen processing and presentation by B cells
- Outline the sequence of helper (T/(TH) cell involvment in
antibody production
- Describe the interplay between TH1 and TH2 cells in the
development of immune responses