5.5 Department of Chemistry and Biochemistry

(Ext. 3521)

5.5.1 OFFICERS OF INSTRUCTION

Professors Emeritii

Thibert, Roger J.; B.A. (Western Ontario), M.S. (Detroit), Ph.D. (Wayne State), F.C.I.C.—1953.

McGarvey, Bruce R.; B.A. (Carleton College), M.A., Ph.D. (Illinois), F.C.I.C.—1972.

Tuck, Dennis G.; B.Sc., Ph.D., D.Sc. (Durham), F.C.I.C., F.R.S.C. (U.K.)—1972.

Professors

McKenney, Donald J.; B.Sc., M.Sc. (Western Ontario), Ph.D. (Ottawa)—1964.

McIntosh, John M.; B.Sc. (Queen's), Ph.D. (M.I.T.), F.C.I.C.—1968.

Drake, John E.; B.Sc., Ph.D., D.Sc. (Southampton), F.C.I.C.—1969.

Stephan, Douglas W.; B.Sc. (McMaster), Ph.D. (Western Ontario)—1982.

Aroca, Ricardo; B.Sc. (Chile), Ph.D. (Moscow State), D.Sc. (Leningrad)—1985.

Jones, William E.; B.Sc., M.Sc. (Mount Allison), Ph.D. (McGill)—1991. (Vice-President, Academic)

Szabo, Arthur G.; B.Sc. (Queen's), M.A., Ph.D. (Toronto), F.C.I.C.—1994. (Head of the Department)

Associate Professors

Rumfeldt, Robert C.; B.Sc. (Loyola, Montreal), Ph.D. (Alberta)—1965.

Hencher, J. Lawrence; B.A., Ph.D. (McMaster)—1967.

Taylor, Keith E.; B.Sc., Ph.D. (Toronto)—1976.

Mutus, Bulent; B.Sc., M.Sc. (Waterloo), Ph.D. (Manitoba)—1982.

Adeli, Khosrow; B.Sc. (Tehran), M.Sc., Ph.D. (Ottawa), Dipl. Clin. Chem. (Toronto)—1988.

Loeb, Stephen J.; B.Sc., Ph.D. (Western Ontario)—1990.

Wang, Suning; B.Sc. (Jilin), Ph.D. (Yale)—1990.

Assistant Professors

Lee, Lana; A.B. (Mount Holyoke), Ph.D. (Alberta)—1986.

Green, James R.; B.Sc. (Windsor), Ph.D. (Waterloo)—1989.

Dutton, Philip J.; B.Sc., Ph.D. (Victoria)—1991.

Christopoulos, Theodore K.; B.Sc., Ph.D. (Athens), Dipl. Clin. Chem. (Toronto)—1992.

Adjunct Professors

Asselstine, Harold S.; B.Sc., M.D. (McGill), F.R.C.P.(C); Medical Director, Medical Laboratories of Windsor—1969.

Draisey, Thomas F.; M.B., Ch.B. (Bristol), F.R.C.Path.; Department of Pathology, Salvation Army Grace Hospital and Windsor Western Hospital Centre—1969.

Taylor, Norman F.; B.A., M.A., D.Phil. (Oxon), F.R.S.C. (U.K.)—1973.

Kovacs, Gregory J.: B.Sc., M.Sc., Ph.D (Toronto)—1991.

Nazri, Gholam-Abbas; B.S., M.S. (Tehran), Ph.D. (Case Western Reserve)—1991.

Adjunct Associate Professors

Foreback, Craig C.; B.A. (South Florida), Ph.D. (South Florida); Director of Clinical Chemistry, Henry Ford Hospital, Detroit —1986.

Yee, George E.; M.D. (Manitoba), F.R.C.Path.; Director of Pathology Laboratories, Metropolitan General Hospital, Windsor—1986.

Cheung, Raphael M.C.; M.D. (Toronto), F.R.C.P.(C); Medical Director, Lipid Clinic, Windsor Western Hospital—1988.

Artiss, Joseph D.; B.Sc., Ph.D. (Windsor); Associate Professor of Pathology, Wayne State University and Technical Director - Chemistry, DMC University Laboratories, Detroit—1994.

Yee, Hugh; B.S., M.S., Ph.D. (Wayne State); Technical Director - Toxicology, DMC University Laboratories, Detroit—1994.

Adjunct Assistant Professors

Drury, Craig F.; B.Sc., M.Sc. (McGill), Ph.D. (Guelph); Soil Microbiologist, Agriculture Canada Research Station, Harrow—1991.

Sellers, Allyson R.; B.A. (Guelph), B.Ed. (Lakehead), M.D. (McMaster), F.R.C.Path.; Anatomic and General Pathologist, Hotel Dieu Hospital, Windsor—1993.

5.5.2 PROGRAMS OF STUDY

The Department of Chemistry and Biochemistry offers programs leading to the Bachelor of Science degree in Honours Chemistry, Honours Biochemistry, Honours Chemistry and Physics, and general degrees in both Chemistry and Biochemistry. These programs are subject to the regulations of the Faculty as outlined in 5.3.1 and 5.3.2.

Preparation for Graduate and Professional Schools

Courses are available to permit the student to become fully prepared for entry into medical, dental, and pharmacy schools, as well as graduate programs in the physical and life sciences. Students should determine as early as possible the specific requirements for graduate or professional schools and programs that they may wish to apply for after completing all or part of a Chemistry or Biochemistry program. (see also 5.3.5.) Advisors are available in the Department.

Languages Other Than English: Since many graduate schools have language requirements, students who may subsequently choose to enter graduate school are strongly advised to consider a selection of courses which includes the prominent scientific languages, French, German and Russian.

Community College Graduates: Graduates of three-year programs in Chemical Technology, Environmental Technology, Industrial Hygiene Technology and Medical Technology may be given substantial credit toward degree programs in Chemistry or Biochemistry. Detailed advice on these matters can be obtained from the Department of Chemistry and Biochemistry.

Standing Required: For admission to any Chemistry or Biochemistry program at the second level, a student must obtain a minimum grade of 5.0 in Chemistry 59-110 and 59-135, or the equivalent. Students in Biochemistry also must obtain a minimum grade of 5.0 in Biology 55-114 and 55-115. Furthermore, for admission to and continuation in any honours program a student must have and maintain a minumum major average of 8.0 and a cumulative average of 5.0.

Graduation Requirements: In order to graduate from the general programs in Chemistry or Biochemistry, a student must achieve a major average of 5.0 in all Chemistry courses and a cumulative average of 5.0. In order to graduate from the honours programs in Chemistry, a student must achieve a minumum major average of 8.0 and a cumulative average of 5.0.

The three honours programs offered by the Department of Chemistry and Biochemistry are accredited by the Chemical Institute of Canada.

PROGRAM REQUIREMENTS

1) The prerequisite for 59-410 shall normally be a major average of 8.0 or consent of the Department. Students lacking the prerequisite must take two courses, as approved by the Department, in lieu of 59-410.

2) Unless otherwise stated, students in Chemistry and Biochemistry are expected to take the course with laboratory where two offerings differing only in the presence or absence of a laboratory component are listed.

General Chemistry

Total courses: thirty.

Major requirements: fifteen courses, including 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, and seven other 300- or 400-level courses.

Other requirements:

(a)

62-110, 62-111, 62-120, both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107), and 64-220;

(b)

four courses from the Faculties of Arts and Social Science, with at least one from each;

(c)

four courses from any department, school, or faculty, excluding Chemistry and Biochemistry;

(d)

one course from any department, school, or faculty.

RECOMMENDED COURSE SEQUENCE

Level 1: ten courses, including 59-110, 59-135, 62-110, 62-111, 62-120, and both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107). (Recommended: 60-104, or 64-151.)

Level 2: <|>ten courses, including 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, and 64-220.

Level 3: ten courses, including seven 300- or 400-level Chemistry and Biochemistry courses.

General Biochemistry

Total courses: thirty.

Major requirements: fifteen courses, including 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 59-320, 59-321, 59-360, 59-361, and 59-365; plus two other courses at the 300 or 400 level.

Other requirements:

(a)

55-114, 55-115, 55-213, 55-243, 62-113, 62-115, 64-102 (or 64-106), and 64-103 (or 64-107); plus one of 60-104 or 64-151;

(b)

four courses from the Faculties of Arts and Social Science, with at least one from each;

(c)

one course from any department, school, or faculty, excluding Chemistry and Biochemistry;

(d)

one course from any department, school, or faculty.

RECOMMENDED COURSE SEQUENCE

Level 1: ten courses, including 55-114, 55-115, 59-110, 59-135, 62-113, 62-115, and both 64-102 and 64-103 (or both 64-106 and 64-107); plus one of 60-104 or 64-151.

Level 2: <|>ten courses, including 55-213, 55-243, 59-235, 59-240, 59-241, 59-250, and 59-261.

Level 3: ten courses, including 59-251, 59-320, 59-321, 59-360, 59-361, and 59-365; plus two other Chemistry and Biochemistry courses.

Honours Chemistry

Total courses: forty.

Major requirements: twenty-four courses, including 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 59-320, 59-321, 59-330, 59-331, 59-340, 59-341, 59-350 (or 59-351), 59-400, and 59-410 (a 6.00 credit hour course); plus six additional courses.

Other requirements:

(a)

62-110, 62-111, 62-120, 62-215, 62-216, both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107), and 64-220;

(b)

four courses from the Faculties of Arts or Social Science with at least one from each;

(c)

two courses from any department, school, or faculty excluding Chemistry and Biochemistry;

(d)

two courses from any department, school, or faculty.

RECOMMENDED COURSE SEQUENCE

Level 1: ten courses, including 59-110, 59-135, 62-110, 62-111, 62-120, and both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107). (Recommended: 60-104 or 64-151.)

Level 2: ten courses, including 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 62-215, 62-216, and 64-220.

Level 3: ten courses, including 59-320, 59-321, 59-330, 59-331, 59-340, 59-341, and 59-350 (or 59-351).

Level 4: ten courses, including 59-400, 59-410 (a 6.00 credit hour course), and six additional Chemistry and Biochemistry courses.

Honours Chemistry and Physics

Total courses: forty.

Major requirements—Chemistry and Biochemistry: sixteen courses, including 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-320, 59-321, 59-330 (or 59-331), 59-342, and 59-400; plus four other courses.

Major requirements—Physics: fourteen courses, including both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107), 64-151, 64-220, 64-221, 64-222, 64-250, 64-261, 64-310, 64-315, 64-322 (or 64-321), and 64-331; plus two other courses at the 300 or 400 level.

Other requirements:

(a)

62-110, 62-111, 62-120, 62-215, 62-216, and 62-218;

(b)

two courses from either of the Faculty of Arts or the Faculty of Social Science;

(c)

two courses from any department, school, or faculty.

RECOMMENDED COURSE SEQUENCE

Level 1: ten courses, including 59-110, 59-135, 62-110, 62-111, 62-120, both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107), and 64-151.

Level 2: ten courses, including 59-235, 59-240, 59-241, 62-215, 62-216, 62-218, 64-220, 64-221, and 64-222.

Level 3: ten courses, including 59-250, 59-251, 59-342, 64-250, 64-261, 64-310, 64-315, 64-322 (or 64-321), and 64-331.

Level 4: ten courses, including 59-320, 59-321, 59-330 (or 59-331), and 59-400; plus four additional Chemistry courses; and two additional Physics courses at the 300 or 400 level.

Honours Biochemistry

Total courses: forty.

Major requirements: twenty courses, namely 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 59-320, 59-321, 59-330 (or 59-331), 59-340, 59-360, 59-361, 59-365, 59-400, 59-410 (a 6.00 credit hour course), 59-464, and 59-468.

Other requirements:

(a)

55-114, 55-115, 55-213, 55-242, 55-243 and one additional Biological Sciences course at the 200 level or higher; plus 62-113, 62-115, 64-102 (or 64-106), 64-103 (or 64-107), and 65-253; and one of 60-104 or 64-151; and one additional Faculty of Science course at the 300 or 400 level.

(b)

four courses from the Faculties of Arts and Social Science, with at least one from each;

(c)

three courses from any department, school, or faculty.

RECOMMENDED COURSE SEQUENCE

Level 1: ten courses, including 55-114, 55-115, 59-110, 59-135, 62-113, 62-115, and both 64-102 and 64-103 (or both 64-106 and 64-107); plus one of 60-104 or 64-151.

Level 2: ten courses, including 55-213, 55-242, 55-243, 59-235, 59-240, 59-241, 59-250, and 59-261.

Level 3: ten courses, including 59-251, 59-320, 59-321, 59-330 (or 59-331), 59-340, 59-360, 59-361, and 59-365.

Level 4: ten courses, including 59-400, 59-410 (a 6.00 credit hour course), 59-464, 59-468, and 65-253.

Combined Honours Programs

For Faculty of Science regulations, see 5.3.2.

Programs combining Chemistry with another major will consist of the following:

Total courses: forty.

Major requirements—Chemistry and Biochemistry: fifteen courses, including 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 59-320, 59-321, 59-330 (or 59-331), and 59-340; plus three additional courses at the 300- or 400-level.

Major requirements—Other Subject: as prescribed by that department or school.

Other requirements:

(a)

62-110, 62-111, 62-120, both 64-110 and 64-111 (or both 64-102 and 64-103, or both 64-106 and 64-107), and 64-220;

(b)

additional courses, if necessary, from any department, school, or faculty to a total of forty courses.

Programs combining Biochemistry with another major will consist of the following:

Total courses: forty.

Major Requirements—Chemistry and Biochemistry: fourteen courses, consisting of 59-110, 59-135, 59-235, 59-240, 59-241, 59-250, 59-251, 59-261, 59-320, 59-321, 59-360, 59-361, 59-365, and either 59-464 or 59-468.

Major requirements—Other Subject: as prescribed by that department or school.

Other requirements:

(a)

55-114, 55-115, 55-243, 62-113, 62-115, and both 64-102 and 64-103 (or both 64-106 and 64-107);

(b)

additional courses, if necessary, from any department, school, or faculty to a total of forty courses.

Minor in Chemistry or Biochemistry

The minors in Chemistry and in Biochemistry consist of six courses, including both 59-110 (or 59-102) and 59-135, or both 59-130 and 59-131, plus three courses at the 200 level or above, and at least one course at the 300 level or above. If the minor is in Biochemistry, at least three of 59-261, 59-360, 59-361, 59-365, 59-464 and 59-468 must be chosen. Selected courses leading to a minor in either area may not consist of antirequisites to courses in the student's degree program. Where two offerings of a course differing only in the presence or absence of a laboratory are available, students are expected to select the one with the laboratory. Students must also remember to select only courses which may be otherwise counted for credit towards their degree programs.

Bachelor of Science (General Science)

See Faculty of Science, 5.3.1.

Bachelor of Science (Science, Technology and Society)

See Faculty of Science, 5.3.1.

5.5.3 COURSE DESCRIPTIONS

All courses listed will not necessarily be offered each year.

The following 100-level Chemistry courses are mutual antirequisites: 59-102, 59-104, 59-110, and 59-130.

The prerequisite of all 200-level courses, unless otherwise indicated, will be both 59-110 (or 59-102) and 59-135, or both 59-130 (or 59-102) and 59-131.

The prerequisite for all 400-level courses will be the consent of the instructor, except as noted.

59-102. Introductory Chemistry I

This course is essentially equivalent to 59-110 and 59-130; however, it is specifically designed for students who lack OAC Chemistry or the equivalent. (Prerequisite: Ontario Level 3 Chemistry SCH3A.) (4 lecture, 3 laboratory hours a week.)

59-104. Introductory Chemistry I

The same as 59-102 but without the laboratory. (Prerequisite: Ontario Level 3 Chemistry SCH3A.) (4 lecture hours a week.) (Not open to students majoring in the Faculty of Science.)

59-110. Topics In General Chemistry

An introduction to selected topics in modern chemistry for science and engineering: properties of matter and solutions, stoichiometry, equilbrium theory and applications, oxidation-reduction reactions, rate processes, atomic and molecular structure. (Prerequisite: OAC Chemistry.) (3 lecture, 3 laboratory hours a week.)

59-130. General Chemistry for Biological Sciences I

Properties of materials and solutions, atomic and molecular structure plus theories of bonding; emphasis on areas of chemistry of interest to biologists. (Prerequisite: OAC Chemistry.) (3 lecture, 3 laboratory hours a week.)

59-131. General Chemistry for Biological Sciences II

A continuation of 59-130 covering topics such as rates of chemical reactions, equilibrium theory, oxidation-reduction reactions, and thermochemistry. (Prerequisite: 59-102 or 59-130.) (3 lecture, 3 laboratory hours a week.)

59-135. Introductory Organic Chemistry I

Introduction to organic chemistry with emphasis on structure, stereochemistry and reactions of aliphatic and alicyclic compounds and their functionalized derivatives. (Prerequisite: 59-102 or 59-110 or consent of instructor) (Antirequisites: 59-230 and 59-232.) (3 lecture, 3 laboratory hours a week.)

59-137. Introductory Organic Chemistry I

The same as 59-135 but without the laboratory. (Prerequisite: 59-102, 59-104, 59-110, or consent of instructor) (Antirequisites: 59-230 and 59-232.) (3 lecture hours a week.) (Not open to students majoring in the Faculty of Science.)

59-191. Organic and Biological Chemistry for Health Sciences

A course of particular interest to students of nursing and other health science areas. The subject matter includes a survey of organic functional groups, the organic chemistry of biomolecules, and a survey of the major metabolic pathways. (Prerequisite: OAC Chemistry.) (Antirequisites: 59-135, 59-137, 59-230, and 59-232.) (2 lecture hours, 1 tutorial hour a week.)

59-230. Organic Chemistry for Biological Sciences

The chemistry of aliphatic and aromatic compounds and their functionalized derivatives with emphasis on areas of interest to students in the biological sciences. This course will be a broader survey of organic functional groups and their reactions, with less emphasis on stereochemistry and mechanism than 59-135. (Prerequisite: 59-102, 59-110, or 59-131.) (Antirequisites: 59-135 and 59-137.) (3 lecture, 3 laboratory hours a week.)

59-232. Organic Chemistry For Biological Sciences

The same as 59-230 but without the laboratory. (Prerequisite: 59-102, 59-104, 59-110, or 59-131; Antirequisite: 59-135 or 59-137.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.)

59-235. Introductory OrganicChemistry II

A continuation of 59-135. Topics include the chemistry of nitrogen-containing compounds, aromatic chemistry and an introduction to spectroscopic methods. (Prerequisite: 59-135 or 59-230.) (2 lecture hours a week.)

59-240. Introductory PhysicalChemistry I

The laws of thermodynamics applied to changes of state and chemical reactions. Spontaneous processes. (Prerequisites: 59-110 and either 62-110 and 62-111 or 62-113 and 62-115.) (3 lecture, 1.5 laboratory hours a week.)

59-241. Introductory Physical Chemistry II

Physical and chemical equilibrium, electrochemistry. (Prerequisite: 59-240.) (2 lecture, 3 laboratory hours a week.)

59-250. Introductory Inorganic Chemistry I

Introduction to chemical bonding including molecular orbital and valence bond models and their application to the stereochemistry and properties of hydrides and halides. Photoelectron, NMR, and vibrational spectroscopy are introduced as complementary tools in the examination of these molecular species. (3 lecture, 1.5 laboratory hours a week.)

59-251. Introductory Inorganic Chemistry II

The coordination chemistry of transition metals will be discussed, with particular reference to the means of physical and spectroscopic characterization. Relevance of such compounds to bio-inorganic systems will also be discussed. (Prerequisite: 59-250.) (3 lecture, 3 laboratory hours a week.)

59-253. Intoductory Inorganic Chemistry II

The same as 59-251 but without the laboratory. (Prerequisite: 59-250.) (3 lecture hours a week.)

59-261. Organic Chemistry of Biomolecules

An extension of the priniciples covered in 59-135 or 59-230 to the structure and properties of organic molecules of biological significance. (Prerequisite: 59-135 or 59-230.) (3 lecture, 3 laboratory hours a week.)

59-263. Organic Chemistry of Biomolecules

The same as 59-261 but without the laboratory. (Prerequisites: 59-135 or 59-137 or 59-230 or 59-232, or consent of instructor.) (3 lecture hours a week.) (Not available for credit to students majoring in Chemistry, Biochemistry, or Biological Sciences.)

59-291. Pharmacology for Health Sciences

A course of particular interest to students of nursing and other health science areas. The principles of pharmacokinetics and pharmacodynamics will be covered utilizing a systems approach to pharmacologic therapies in health care. (Prerequisites: 55-204, 55-205, and one of 59-191, 59-135, 59-137, 59-230, or 59-232.) (2 lecture hours, 1 tutorial hour a week.) (May be taken by B.Sc. students for credit, but does not count as a Biochemistry course towards the fulfillment of the requirements for the B.Sc. degree.)

59-320. Analytical Chemistry

Solution chemistry. Precipitation, complexation, electron transfer, and proton transfer reactions. Potentiometric, polarographic and amperometric titration techniques. Data analysis and chemical statistics. (Prerequisites: both 59-110 (or 59-102) and 59-135, or both 59-130 (or 59-102) and 59-131, plus both 62-110 and 62-111 or both 62-113 and 65-253, or consent of instructor.) (3 lecture, 3 laboratory hours a week.)

59-321. Principles of Instrumental Analysis

Electronic and digital circuits. Microprocessor controlled instrumentation and microcomputer interfacing. Data acquisition and data processing in electrochemical and spectroscopic techniques. (Prerequisite: 59-320.) (2 lecture hours, 1 tutorial hour, 3 laboratory hours a week.)

59-330. Intermediate Organic Chemistry I

Structure elucidation and the use of spectroscopic techniques in organic chemistry. The laboratory portion focuses on synthetic chemistry, with application of spectroscopic methods. (Prerequisite: 59-235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.)

59-331. Intermediate Organic Chemistry II

The methods of organic synthesis and the reaction mechanisms involved. (Prerequisite: 59-235 or consent of instructor.) (3 lecture, 3 laboratory hours a week.)

59-332. Intermediate Organic Chemistry I

The same as 59-330 but without the laboratory. (Prerequisite: 59-235 or consent of instructor.) (3 lecture hours a week.)

59-333. Intermediate Organic Chemistry II

The same as 59-331 but without the laboratory. (Prerequisite: 59-235 or consent of instructor.) (3 lecture hours a week.)

59-340. Intermediate Physical Chemistry I

Collisions, transport properties and rates of chemical reactions. (Prerequisite: 59-241.) (2 lecture, 3 laboratory hours a week.)

59-341. Quantum Chemistry and Spectroscopy

Introduction to quantum chemistry, rotational and vibrational spectroscopy of diatomic and polyatomic molecules, visible and ultraviolet and Raman spectroscopy. (Prerequisite: 59-340.) (3 lecture, 3 laboratory hours a week.)

59-342. Intermediate Physical Chemistry I

Same as 59-340 but without laboratory. (Prerequisite: 59-241 and consent of instructor.) (2 lecture hours a week.)

59-343. Quantum Chemistry and Spectroscopy

The same as 59-341 but without the laboratory. (Prerequisite: 59-340 or 59-342.) (3 lecture hours a week.)

59-350.Intermediate Inorganic Chemistry

An introduction to main group chemistry. This will start as a continuation of 59-250 and deal with a systematic examination of the structure and reactivity of simple and complex oxides and halides of the main group elements. Additional topics such as main group chains, rings, and cages, non-aqueous solvents and main group organometallic compounds will also be discussed. (Prerequisite: 59-250.) (3 lecture, 3 laboratory hours a week.)

59-351. Organometallic Chemistry

The course will cover the structure, synthesis, spectroscopic properties, and reactivity of transition metal complexes which incorporate M-C and M-H bonds. The principles of bonding and fluxionality, as well as applications of this chemistry in catalytic processes of industrial interest will be discussed. (Prerequisite: 59-251.) (3 lecture, 3 laboratory hours a week.)

59-352.Intermediate Inorganic Chemistry

The same as 59-350 but without the laboratory. (Prerequisite: 59-250.) (3 lecture hours a week.)

59-353. Organometallic Chemistry

The same as 59-351 but without the laboratory. (Prerequisite: 59-251 or 59-253.) (3 lecture hours a week.)

59-360. Intermediary Metabolism I

Catabolism and the generation of phosphate bond energy. Laboratory exercises are associated with the analytical and preparative procedures of biochemistry. (Prerequisite: 59-261.) (3 lectures, 3 laboratory hours a week.)

59-361. Intermediary Metabolism II

The utilization of phosphate bond energy will be illustrated by carbohydrate, fatty acid and lipid biosynthesis, hormonal (G-proteins) and metabolite regulation, biological membranes (structure and transport mechanisms) and contractile processes (muscle biochemistry). (Prerequisite: 59-360.) (2 lectures, 3 laboratory hours a week.) (Limited enrolment.)

59-362. Intermediary Metabolism I

The same as 59-360 but without the laboratory. (Prerequisite: 59-261 or 59-263.) (3 lecture hours a week.)

59-363. Intermediary Metabolism II

The same as 59-361 but without the laboratory. (Prerequisite: 59-360 or 59-362.) (2 lecture hours a week.)

59-365. Protein and Nucleic Acid Chemistry

The covalent and three dimensional structures of these macromolecules will be described in conjunction with study of the chemical and physical methods used in their purification and characterization. (Prerequisite: 59-261.) (2 lecture hours a week.)

59-400. Seminar

Discussion of selected topics from the current literature. (1 lecture hour a week over two terms; 3.00 credit hours; under special circumstances may be completed in one term.) (Normally open to students in only Honours Chemistry, Honours Chemistry and Physics, or Honours Biochemistry.)

59-410. Research

Original laboratory research under the direction of a faculty member. (1 lecture, 12 laboratory hours a week) (A 6.00 credit hour course given over two terms.) (See above, "Program Requirements".)

59-421. Advanced Analytical Chemistry

Special topics in analytical chemistry. (2 lecture hours a week.)

59-431. Special Topics in Organic Chemistry

Topics may include polymer chemistry, natural product chemistry, advanced synthetic methodology, or design and execution of organic syntheses. (Prerequisite: 59-331 or consent of instructor.) (2 lecture hours a week.)

59-435. Advanced Organic Chemistry

Physical organic chemistry. Includes molecular orbital theory, stereochemistry, thermodynamics, and reaction mechanisms. (Prerequisite: 59-331 or consent of instructor.) (2 lecture hours a week.)

59-440. Kinetics and Photochemistry

Rates of reaction, theory and mechanisms, solution kinetics and photochemical kinetics. (2 lecture hours a week.)

59-441. Statistical Thermodynamics

Development of statistical thermodynamics and its application to theories of gases, condensed states and chemical equilibria. (2 lecture hours a week.)

59-445. Advanced Physical Chemistry

Special topics in physical chemistry. (2 lecture hours a week.)

59-450. Group Theory in Chemistry

Various applications of group theory to the study of organic and inorganic systems. (Prerequisite: 59-341, or 59-343, or consent of instructor.) (2 lecture hours a week.)

59-451. Special Topics in Inorganic Chemistry

Advanced topics in inorganic chemistry and organometallic chemistry may include analytical and spectroscopic methods of use to the inorganic chemist, advanced topics in main group chemistry, coordination chemistry, organometallic chemistry, or the chemistry of the lanthanides and actinides. (Prerequisite: 59-351 or 59-353.) (2 lecture hours a week.)

59-464. Enzymology

Mechanisms of enzyme action will be covered in terms of kinetics, functional groups responsible for catalysis and specificity and the design of active-site directed irreversible inhibitors. (2 lecture hours a week.)

59-466. Special Topics in Biochemistry

(2 lecture hours a week.)

59-468. DNA Science and Diagnostics

An advanced lecture and laboratory course dealing with DNA science and the application of DNA technology in the understanding and diagnosis of human disease. The lectures cover the biochemistry and expression of DNA and RNA at the molecular level, the theory and practice of recombinant DNA technology, and the application of DNA probes in diagnosis of human disease. The laboratory component involves construction and cloning of a recombinant DNA molecule. (Limited enrolment.)

59-470. Advanced Quantum Chemistry

Perturbation and variation theories. Theories of many electron atoms and general theories of chemical bonds in diatomic and polyatomic molecules. (Prerequisite: 59-341 or 59-343.) (2 lecture hours a week.)

59-476. Special Topics in Chemistry

(2 lecture hours a week.)


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