4.1.1 GRADUATE FACULTY
McGarvey, Bruce R.; B.A. (Carleton College), M.A., Ph.D. (Illinois), F.C.I.C.—1972.
Thibert, Roger J.; B.A. (Western Ontario), M.S. (Detroit), Ph.D. (Wayne State), F.C.I.C.—1953.
Tuck, Dennis G.; B.Sc., Ph.D., D.Sc. (Durham), F.C.I.C., F.R.S.C. (U.K.)—1972.
McKenney, Donald J.; B.Sc., M.Sc. (Western Ontario), Ph.D. (Ottawa)—1964.
McIntosh, John M.; B.Sc. (Queen's), Ph.D. (M.I.T.), F.C.I.C.—1968.
Drake, John E.; B.Sc., Ph.D., D.Sc. (Southampton), F.C.I.C.—1969.
Taylor, Keith E.; B.Sc., Ph.D. (Toronto)—1976.
Mutus, Bulent; B.Sc., M.Sc. (Waterloo), Ph.D. (Manitoba)—1982.
Stephan, Douglas W.; B.Sc. (McMaster), Ph.D. (Western Ontario)—1982.
Aroca, Ricardo; B.Sc. (Chile), Ph.D. (Moscow State), D.Sc. (Leningrad)—1985.
Loeb, Stephen J.; B.Sc., Ph.D. (Western Ontario)—1990.
Jones, William E.; B.Sc., M.Sc. (Mount Allison), Ph.D. (McGill)—1991. (Vice-President, Academic)
Szabo, Arthur G.; B.Sc. (Queen's), M.A., Ph.D. (Toronto), F.C.I.C.—1994. (Head of the Department)
Lee, Lana; A.B. (Mount Holyoke), Ph.D. (Alberta)—1986.
Adeli, Khosrow; B.Sc. (Tehran), M.Sc., Ph.D. (Ottawa), Dipl. Clin. Chem. (Toronto)—1988.
Green, James R.; B.Sc. (Windsor), Ph.D. (Waterloo)—1989.
Christopoulos, Theodore K.; B.Sc., Ph.D. (Athens), Dipl. Clin. Chem. (Toronto)—1992.
Dutton, Philip J.; B.Sc., Ph.D. (Victoria)—1991.
Adjunct Professors
Asselstine, Harold S.; B.Sc., M.D. (McGill), F.R.C.P.(C); Medical Director, Medical Laboratories of Windsor—1969.
Draisey, Thomas F.; M.B., Ch.B. (Bristol), F.R.C.Path.; Department of Pathology, Salvation Army Grace Hospital and Windsor Western Hospital Centre—1969.
Taylor, Norman F.; B.A., M.A., D. Phil. (Oxon), F.R.S.C. (U.K.)—1973.
Zak, Bennie; B.S., Ph.D. (Wayne State); Department of Pathology. Wayne State University School of Medicine, Detroit—1975.
Spitz, Werner U.; M.D. (Hadassah); Pathologist, Macombe Munroe Counties Medical Examiner—1978.
Kovacs, Gregory J.: B.Sc., M.Sc., Ph.D (Toronto)—1991.
Nazri, Gholam-Abbas; B.S., M.S. (Tehran), Ph.D. (Case Western Reserve)—1991.
Shore, Joseph; B.S. (Cornell), M.S. (Massachusetts), Ph.D. (Rutgers); Department of Pathology, Henry Ford Hospital, Detroit-1996
Foreback, Craig C.; B.A. (South Florida), Ph.D. (South Florida); Director of Clinical Chemistry, Henry Ford Hospital, Detroit —1986.
Yee, George E.; M.D. (Manitoba), F.R.C.Path.; Director of Pathology Laboratories, Metropolitan General Hospital, Windsor—1986.
Cheung, Raphael M.C.; M.D. (Toronto), F.R.C.P.(C); Medical Director, Lipid Clinic, Windsor Western Hospital—1988.
Drury, Craig F.; B.Sc., M.Sc. (McGill), Ph.D. (Guelph); Agriculture Canada—1991.
Artiss, Joseph D.; B.Sc., M.Sc., Ph.D. (Windsor)—1993.
The Department provides facilities for students wishing to proceed to the degrees of Master of Science and Doctor of Philosophy. Students may enrol in graduate studies in Chemistry and Biochemistry. One field of study in Chemistry is Clinical Chemistry, which is approved by the Canadian Academy of Clinical Chemistry and is accredited by the Commission on Accreditation in Clinical Chemistry (U.S.A.).
In addition to the general requirements outlined in 1.5.2, the following requirements must be met by all students proceeding to the Ph.D. degree:
1) Course Work: Candidates must complete successfully at least eight courses (or four courses if the candidate enters the program with an M.Sc. degree) chosen from the available graduate offerings in the student's field or from related and cognate courses, with the approval of the Department. Credit for up to a maximum of two courses may be given for equivalent courses taken as an undergraduate, provided that a grade of at least A- was achieved in the courses.
Ph.D. Candidates who are studying in the field of Clinical Chemistry are required to take the following core courses: 59-564, 59-680, 59-681, 59-682, 59-683, 59-684, and 59-686. Candidates who have taken any of these courses for an M.Sc. degree will be given credit for those courses successfully completed. They will also participate in a Hospital Rotation Program which is designated as the course, 59-689.
The program in the field of Clinical Chemistry is approved by the certification committee of the Canadian Academy of Clinical Chemistry as fulfilling all of the academic requirements, and one year of the required practical experience. The Ph.D. program is also accredited by the Commission on Accreditation in Clinical Chemistry (U.S.A.).
2) Seminars: In addition to the above course work, students must attend the regular departmental Seminar (59-795) throughout their Ph.D. studies and present at least one seminar on their research as a fulfilment of this requirement.
3) Dissertation: The principal requirement for the Ph.D. degree is the presentation of a dissertation which embodies the results of an original investigation (59-798). For general requirements of the dissertation, see 1.5.3.
A student who fails to achieve satisfactory performance in all aspects of the program (e.g., course work, seminars, and dissertation work) may be required to withdraw.
4) Doctoral Committee: The Ph.D. committee is chosen in the manner described in 1.5.2. This committee will meet with the student annually to review his or her progress. As part of this review the student will present a short seminar on his or her research progress.
5) Examinations: In addition to examinations connected with course work, all students proceeding to the Ph.D. degree must meet the following requirements:
(a) Qualifying Examination for Admission to the Ph.D. Program: Students who wish to transfer to a Phd. program from an M.Sc. program will be required to satisfactorily complete an oral comprehensive examination in the first twenty-four months of graduate study prior to transfer. For students who enrol directly in a Ph.D. program, the qualifying examination must be completed within the first twelve months of the doctoral program. The examination will take the form of a ten to twenty minute presentation of the student's research work to date, followed by a question and answer session in which the student's depth of knowledge of the field of research and the underlying chemical and/or biochemical principles will be examined. The student may be assessed by a committee of three members comprised of the research advisor and two other faculty members from the Department. As a guide to the student, the committee may provide some directed readings prior to the examination. The student will be expected to understand the subject matter and background of these topics. A grade of Pass or Fail will be given. In the event of a failing grade, the student may be allowed a second examination within one month, or a specific assignment for subsequent evaluation at the discretion of the examining committee. It may be possible that the student will not be allowed to repeat the examination.
(b) Final Examination: Each candidate will take a final oral examination in defense of the dissertation on the recommendation of the doctoral committee. An external examiner, chosen for acknowledged scholarship in the appropriate field of chemistry, biochemistry or clinical chemistry, will normally be present during the oral examination. The external examiner will be selected by the doctoral committee, subject to the approval of the Head of the Department and the Dean of Graduate Studies and Research. The examination will be public and will involve a short seminar presentation by the candidate. The examination will be chaired by the Dean of Graduate Studies and Research or delegate.
In addition to the general requirements and stipulations outlined in 1.6.2 for the Master's degree, the following requirements must be met by students proceeding to the M.Sc. degree.
1) Course Work: Candidates must complete successfully at least four courses chosen from the available graduate offerings in the student's field or from related and cognate courses, with the approval of the Department. Credit for up to a maximum of two courses may be given for equivalent courses taken as an undergraduate, provided a grade of at least A- was achieved in the course.
M.Sc. candidates in Clinical Chemistry will be required to take the following core courses: 59-680, 59-681, 59-682, and 59-683. These candidates will also take a Practical Laboratory Methodology course (59-589).
The M.Sc. program in Clinical Chemistry is accredited by the Commission on Accreditation in Clinical Chemistry (U.S.A.). This program has been approved by the National Registry in Clinical Chemistry (U.S.A.) as fulfilling all of the academic requirements and a portion of the practical experience for certification by examination at the Clinical Chemist level.
2) Seminars: In addition to the above course work, students must attend the regular departmental Seminar (59-795) throughout their M.Sc. studies and present at least one seminar on their research as a fulfilment of this requirement.
3) Thesis: A student must undertake original research and embody the results in a thesis (59-797). The student will then be examined by a committee.
A student who fails to achieve satisfactory performance in all aspects of the program (e.g., course work, seminars, thesis work or major critique) may be required to withdraw.
4) Master's Committee and Final Examinations: The Master's committee is chosen in the manner described in 1.6.2. The final examination will take the form of an open seminar in the presence of the Master's committee (see 1.6.2). The examination will be open to the public.
Postdoctoral trainees will be selected from candidates who hold a Doctor of Philosophy in Biochemistry or Chemistry. Trainees may also be chosen from graduates in other related fields, provided that their training in chemistry and biochemistry is demonstrably adequate.
1) Residence Requirements: The postdoctoral diploma program is of three years duration on a full-time basis, i.e., thirty-six months. This period may not be counted as residence for a Ph.D. program at the University of Windsor.
2) Course Work: Trainees in this program must successfully complete the following minimum course work:
(a) Clinical Biochemistry (59-680 and 59-681), Biochemical Diagnosis of Disease (59-682 and 59-683), Pathophysiology (59-684), Advanced Bioanalytical Topics (59-686) and DNA Science and Diagnostics (59-564).
(b) Seminar (59-795) to be taken each year in which the trainee is registered.
(c) Clinical Chemistry Laboratory Methodology (59-589) and Clinical Chemistry Research and Development (59-689) for a total of 2000 hours. These courses will be in the form of practical laboratory experience at one or more of the following hospitals in Windsor: Hotel Dieu/Grace Hospital, Windsor Regional Hospital; or at Henry Ford Hospital or Detroit Medical Centre in Detroit, Michigan.
Trainees will be expected to undertake an original piece of research of publishable standard and to be prepared to present it at a scientific meeting. The research may be in the fields of Clinical Chemistry, Biochemistry of Disease, or Biochemistry.
3) Additional Course Requirements: A trainee may be required to take a minimum of six courses. These courses will be assigned to the trainees as required in order to given them a thorough background in the appropriate areas of Chemistry, Biochemistry, and Biology. Advanced standing will normally be granted for courses previously taken.
Any trainee who fails to maintain satisfactory standing in course work, Clinical Chemistry Laboratory Methodology (59-589) and Clinical Chemistry Research and Development (59-689), or research, may be required to withdraw.
4) Diploma Committee: The Head of the Department will establish the trainee's diploma committee in consultation with the Dean of Graduate Studies and Research. This committee will consist of four members, three of whom will be chosen from the Chemistry Department, and will include the Adjunct Professor at the appropriate hospital. The committee will meet with the trainee to review his or her progress as necessary.
September—April: course work and initiation of a research project. May—August: Clinical Chemistry Laboratory Methodology (59-589), 700 Hours minimum. This latter portion of time (seventeen weeks) will be spent obtaining practical experience in a hospital laboratory under the joint direction of a faculty member of the University and the pathologist, who is an Adjunct Professor in the Department of Chemistry and Biochemistry at the University. During this period the trainee will be required to obtain a reasonable mastery of the various operations of a clinical chemistry laboratory. Rotation through the various areas of the laboratory, as well as various sections of the clinical chemistry laboratory, will be required. At this stage orientation regarding administration of the laboratory will be carried out.
Remaining course work, if any, will be completed during the second year, and research will be continued. The time distribution between the hospital experience and university/hospital research (59-689) will be on a 40%/ 60% basis in all the following periods:
1) Two months will be spent in special and developmental chemistry, and further experience in laboratory administration will be gained.
2) Four months will be spent in developmental chemistry, and the administration of a section of the clinical chemistry laboratory will be undertaken.
3) Six months will be spent in the administration of the clinical chemistry laboratory (gradually taking over the major administrative function of the entire clinical chemistry laboratory) under the supervision of the Adjunct Professor.
4) Two months will be spent in molecular diagnosis of disease and DNA diagnostics.
In the last year, the trainees will train in other areas of laboratory medicine including immunology, hematology, and microbiology. The trainees will spend at least eight weeks in each of the above areas at one of the designated hospitals.The remaining time will be devoted to research at either the university or one of the hospital sites. During this period the trainees will also be exposed to informatics and management aspects of the clinical laboratory.
In order to ensure that the trainees obtain maximum experience in all the phases of clinical chemistry available in Windsor, rotation from hospital to hospital will occur as required during the latter training period.
Participation in Professional Meetings: During the second year, trainees will be strongly encouraged to attend a meeting of clinical chemists (e.g., Canadian Society of Clinical Chemists, American Association for Clinical Chemistry) and present a paper on the subject of their research. The subject of this paper will, if possible, be submitted for publication.
Trainees will also be required to participate in and give conferences dealing with Clinical Chemistry or Clinical Biochemistry on a regular basis along with other clinical chemists, graduate students in Clinical Chemistry and the Adjunct Professors from the affiliated hospitals.
The Postdoctoral Diploma is approved as fulfilling all of the academic requirements and the required practical experience by the certification committee of the Canadian Society of Clinical Chemists. The Postdoctoral Program is accredited by the Canadian Society of Clinical Chemists and the Commission on Accreditation in Clinical Chemistry (U.S.A.).
All of the courses listed will not necessarily be offered in any one year. Topics courses may be taken several times provided the course content is different. Where prerequisites are not stated, consent of the instructor is required.
(Prerequisite: 59-321. (2 lecture hours a week.)
Topics may include polymer chemistry, natural product chemistry, physical organic chemistry, or design and execution of organic syntheses. (Prerequisite: 59-331 or consent of instructor.) (2 lecture hours a week.)
Physical organic chemistry. Includes molecular orbital theory, stereochemistry, thermodynamics, and reaction mechanisms. (Prerequisite: consent of instructor.) (2 lecture hours a week.)
Development of statistical thermodynamics and its application to theories of gases, condensed states, and chemical equilibria. (2 lecture hours a week.)
Theory and applications of FT NMR in chemical problems, special techniques such as T1, T2 measurements, cross polarization, "magic angle" spinning, 2D spectroscopy, DEPT pulse sequences, and others will be covered. (2 lecture hours a week.)
(2 lecture hours a week.)
Electronic and vibrational spectroscopy of gases, liquids, and solids. Theory and practice of infrared and Raman spectroscopy. Theory and applications of electron spin resonance spectroscopy. (2 lecture hours a week.)
Various applications of group theory to the study of organic, inorganic, and organometallic systems. (3 lecture hours a week.)
Topics to be arranged by the instructor, based primarily upon new developments in the field as illustrated by the current research interests of the faculty, as well as by a study of the current literature. (2 lecture hours a week.)
Theoretical and experimental aspects of single crystal X-ray diffraction methods for the determination of molecular structures. (2 lecture hours a week.)
An advanced lecture and laboratory course dealing with DNA science and the application of DNA technology in the understanding and diagnosis of human disease. The lectures cover the biochemistry and expression of DNA and RNA at the molecular level, the theory and practice of recombinant DNA technology and the application of DNA probes in the diagnosis of human disease. The laboratory component involves construction and cloning of a recombinant DNA molecule. (Prerequisites: 59-360, 59-361, and 59-365, or consent of instructor; antirequisite: 59-468.) (2 lecture hours, 1 laboratory hour a week.)
The structure and function of artificial and natural membranes. Special consideration will be given to the identification and function of membrane proteins. (Prerequisites: 59-360 and 59-361 or 59-362 and 59-363, or equivalent.) (2 lecture hours a week.)
Perturbation and variation theories. Theories of many electron atoms and general theories of chemical bonds in diatomic and polyatomic molecules. (Prerequisite: 59-341 or equivalent.) (3 lecture hours a week.)
Analysis of drugs and other toxic substances in biological fluids. The metabolism of drugs as well as the symptomology of poisoning of common therapeutic drugs and the more common industrial chemicals will be discussed. (Prerequisites: 59-360 and 59-361 or 59-362 and 59-363, or consent of instructor.) (2 lecture hours a week.)
A detailed study of the existing clinical chemistry laboratory procedures. Seminars, papers, and field trips will be required. (Minimum 500 hours.)
A special course of studies with content and direction approved by the student's research advisor and supervisory committee. Although there may be no formal lecture requirements, the course will be equivalent to three one-hour lectures a week for one term. The student will be required (a) to produce a critical review which will be assessed by his or her supervisory committee; the presentation and standard of the review must be appropriate for publication in a scientific journal; (b) to spend one term working in an agreed industrial setting; the quality of work will be assessed by the supervisory committee. This work may be related to but not part of the research undertaken in 59-797 or 59-798. (Prerequisite: approval of the Department.)
The course cannot be repeated for credit under (a) above. Under normal circumstances, M.Sc. students may take this course only once; Ph.D. students may register under (b) above for two terms of this industrial experience.
Surface spectroscopic techniques and their application to the analysis of chemisorbed and physisorbed species and monomolecular layers. (Prerequisite: 59-321 or equivalent.) (2 lecture hours a week.)
A study of some important organic reactions with emphasis on their practical application in synthesis. (Prerequisites: 59-330 and 59-331, or consent of instructor.) (2 lecture hours a week.)
The design, execution, and methodology of total syntheses of complex molecules will be discussed. Emphasis will be placed on both retrosynthetic pathways and execution. (Prerequisites: 59-330 and 59-331, or consent of instructor.) (2 lecture hours a week.)
Topics to be arranged by the instructor, based primarily upon new developments in the field as illustrated by the current research interests of the faculty, as well as by a study of the current literature. (Prerequisites: 59-330 and consent of instructor.) (2 lecture hours a week.)
Special topics in organic chemistry will be described. Some of these may include natural product chemistry, organometallic chemistry or heterocyclic chemistry. (Prerequisite: consent of instructor.) (2 lecture hours a week.)
A survey of structure, mechanism, and theory in organic chemistry. (Prerequisite: consent of instructor.) (2 lecture hours a week.)
A detailed study of selected advanced topics in organometallic chemistry. Typical subjects include (at the discretion of the instructors) main group organometallic chemistry; thermochemical methods in organometallic chemistry; catalysis by organometallics, detailed structural studies. (2 or 3 lecture hours a week.)
Topics to be arranged by the instructor, based primarily upon new developments in the field as illustrated by the current research interests of the faculty, as well as by a study of the current literature. (2 lecture hours a week.)
Spectroscopic applications to inorganic systems. Typical of topics covered from year to year are optical spectroscopy, vibrational spectroscopy and normal coordinate analysis, ESR and NMR spectroscopy, and photoelectron spectroscopy. (2 lecture hours a week.)
Protein chemistry; chemical modification, protein folding, post-translational modification, lipoproteins, and glycoproteins. (Prerequisite: 59-365 or equivalent.) (2 lecture hours a week.)
Biophysical chemistry; advanced kinetic techniques, pre-steady state, perturbation based methods, review of instrumentation, and examples of how these techniques are currently used to solve biochemical problems. (Prerequisite: 59-660.) (2 lecture hours a week.)
(Prerequisites: 59-360 and 59-361, or 59-362 and 59-363, or equivalent.) (2 lecture hours a week.)
Topics to be selected by registrants but will generally be molecular orbital calculations for organic and inorganic chemists. (2 lecture hours a week.)
An advanced lecture course dealing with the application of current techniques in clinical chemistry in the diagnosis of human disease. The various aspects of a clinical chemistry laboratory and its role in laboratory medicine will be discussed as well as the new advances in the development of clinical laboratory instrumentation.
The continuation of Clinical Biochemistry I. An advanced lecture course dealing with the application of current techniques in clinical chemistry in the diagnosis of human disease. The various aspects of a clinical chemistry laboratory and its role in laboratory medicine will be discussed as well as the new advances in the development of clinical laboratory instrumentation.
An advanced lecture course dealing with the biochemistry of human disease, including various aspects of physiological chemistry.The molecular and biochemical basis of human disease will be discussed together with current approaches to the laboratory diagnosis of human disease. The major human organ systems will be discussed in terms of physiology, biochemistry, pathophysiology, and laboratory investigation.
The continuation of Biochemical Diagnosis of Human Disease I. An advanced lecture course dealing with the biochemistry of human disease, including various aspects of physiological chemistry.The molecular and biochemical basis of human disease will be discussed together with current approaches to the laboratory diagnosis of human disease. The major human organ systems will be discussed in terms of physiology, biochemistry, pathophysiology, and laboratory investigation.
Introductory course in human pathology with special emphasis on chemical aspects of disease. An examination of the interrelationships and homeostatic control of the major biochemical parameters in health, and the cause and nature of the anomalies of these parameters occurring in disease. A case-oriented approach to the diagnosis of disease based primarily on examination of the biochemical parameters, with the aim not only of identifying the disease, but also of explaining the significance of the pertinent biochemical parameters. (Prerequisites: Biology 55-110 and 55-111, 59-360 or 59-362, or equivalent, and consent of instructor.) (2 lecture hours a week and demonstrations.)
(Prerequisite: 59-360 or 59-362, or equivalent.) (2 lecture hours a week.)
Original research and comparative studies leading to the development of new clinical chemistry methods. Seminars and papers will be required. (Prerequisite: 59-589.) (Minimum 500 hours.)
This course focuses on the development and presentation of a research proposal, as well as the cultivation of a wide base of knowledge of the chemical and biochemical literature. Techniques of research proposal composition, with particular reference to subject area, budgetary considerations, and written and oral presentation techniques will be discussed. The student will be required to develop and defend his or her own research proposal in chemistry and/or biochemistry. The subject of this proposal must not be from the research work undertaken for the Ph.D. thesis. A written proposal will be submitted to the student's advisory committee and will be followed by an oral presentation and defense of the proposal. The advisory committee will evaluate the originality, the significance, the clarity of the written and oral presentation, and the student's knowledge of the area in the defense. (Prerequisite: registration in the Ph.D. program. The oral presentation and proposal defense will take place during the term of registration.)