Corona Viruses

fackrel@Uwindsor.ca

Corona.ppt

Corona Viruses

• Structure

• Classification

• Multiplication

• Clinical manifestations

• Epidemiology

• Diagnosis

• Control

Baron’s Web Site

Structure

• Spherical or pleomorphic 80-100 nm

• Enveloped
  • club shaped glycoprotein spikes

• ss RNA sense strand

PPT Slide

Classification

• Crown of envelope glycoproteins

• 2 serotypes
  • OC43 like
  • 229E like

Multiplication

• Virus enters nasal epithelium

• Uncoats

• ssRNA transcribed >>> translated

• mRNA nested set
  • common 3’ ends
  • only unique portion of 5’ translated

Clinical Manifestations

Diarrhea in children

RARE!

Corona Virus Pathogenesis

Nasopharynx

Nasal Secretions

coryza

Epidemiology

• local epidemics

• Peak incidence in Winter

• last few weeks- months

Diagnosis

• Clinically
  • undistinguished from other colds

• Laboratory
  • increase in antibody titre over time
  • virus difficult to isolate

Control

• Treat symptoms

• Improve hygiene

• No vaccines

• No specific antivirals

DONE!!!