Antibiotics

13/10/00


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Table of Contents

Antibiotics

Outline

History

Salvarsan 606

Prontosil

Penicillin

Antimicrobial Therapy

Ideal Properties of an Antibiotic

More Characteristics

Still More Characteristics

Sources of Antibiotics

Mechanisms of Drug Action

Sulfa Drugs

Sulfa vs PABA

Structure of Sulfa Drugs

Folic Acid Metabolism

Folic Acid Inhibition

Antibiotic Synergism

Antibiotic Synergism

Major Groups of Antibiotics

Major Groups of Antibiotics

Major Groups of Antibiotics

Major Groups of Antibiotics

PENEMS

Adverse Effects of Antibiotics

Adverse Effects of Antibiotics

Mode of Action of Antibiotics

Mode of Action of Antibiotics

Bacterial Cell Wall

Synthesis of peptidoglycan (1/4)

Synthesis of peptidoglycan (2/4)

Synthesis of peptidoglycan (3/4)

Synthesis of peptidoglycan (4/4)

Inhibit Synthesis of Cell Wall

Inhibition of Cell Wall Synthesis

Inhibition of cell wall synthesis

Inhibition of Cell Wall Synthesis

Natural Penicillins

Semi Synthetic Penicillins

Semi Sythetic Penicillins -2

Structure of Penicillin

Hydrolysis of Beta Lactam Ring

Comparison of Structures

Pen G in Blood

Damage Cell Membrane

Injury of Plasma Membrane

Polymyxin action

Inhibit Protein Synthesis

Inhibition of Translation

Translation

Inhibition of Peptide Bond

Inhibition of Ribosome Movement

Inhibition of tRNA Attachment

Misreading mRNA

Inhibit Nucleic acid Synthesis

Inhibition of DNA Replication

Inhibit Nucleic Acid Synthesis

Acylovir vs Deoxyguanosine

Inhibition of Transcription

Antimetabolites

Inhibited metabolites,Synthesis

Drug Resistance

Development of Drug Resistance

Plasmids

Transposons

Clinical Trials

Minimum Inhibitory Concentration

Kirby-Bauer Plate Sensitivity

Subjects Tested for Antimicrobial Levels

Disk Diffusion Tests

Author: Hugh B. Fackrell

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