Antimicrobial Drugs

Readings Presentation Key Terms Multiple Choice Quizzes Questions Updated 19/02/01
Learning can be a bridge between doing and thinking.
But there is a danger that the person who uses
learning as a bridge between doing and thinking
may get stuck in learning and never get into thinking
Laura Riding Jackson
   

 

Who am I? Although I coined the term complement I am most famous for developing the concept that the body will do everything possible to avoid and auto immune response. I shared the Nobel Prize in 1908 with Elie Metchnifkoff.

 

 

Antimicrobial Drugs
  Anti Microbial Testing    
Baron
Medical Microbiology
Chap 11
Antimicrobial Chemotherapy		 Brock 9th Ed
Biology of Microorganisms
Chap 18
Microbial Growth Control
Tortora:
Microbiology An Introduction
Chapt 20 Antimicribial Drugs		 Jacquelyn Black 4th Ed
Microbiology:
Principles & Explorations
Chap 13
Antimicrobial Therapy
Presentation Slides Web Animation Download
Antibiotics  

The Challenge of Antibiotic Resistance Stuart B Levy Scientific American March 1998

KEY TERMS
antimicrobic chemotheraphy antibiotic erythromycin
selective toxicity broad spectrum antibiotic superinfection chloroamphenicol
penicillin PABA Sulfonimide tetracylcines
trimethoprim rifamycin polymyxin B aminoglycosides
semisynthetic penicillins bacitracin vancomycin cycloserine
penicillinase chemotherapeutic synergism chemotherapeutic antagonsim ethambutol
isoniazid (INH)      

SHORT ANSWER QUESTIONS

  1. Compare the mode of action of polymyxin B, bacitracin and neomycin
  2. Describe two tests for microbial susceptibility to chemotherapeutic agents
  3. Compare and compare chemotherapeutic synergism and antagonism
  4. Describe the mechanisms of drug resistance
  5. Identify the microbes that produce most antibiotics
  6. Describe the problems of chemotherapy for viral, fungal, protozoan and helminthic infections
  7. List five modes of action of antimicrobial drugs
  8. List five drugs discussed in class or in the textbookthat inhibit cell wall synthesis
  9. List five drugs discussed in class ar in the textbook that inhibit protein synthesis
  10. list the advantages of each of the following over penicillin : semisynthetic penicillin, cephalosporins and vancomycin
  11. Explain why INH and ethanumbutol are antimycobacterial agents
  12. What is the advantages of longer retatention of an antibiotic in the body?
  13. Why are cephalosporins resistant to penicillinase
  14. Describe how each of the following inhibits protein synthesis: aminoglycosides, tetracyclines, chlorampenicol, macrolides
  15. Describe how rifamycins and quinolones kill bacteria
  16. Describe how sulfa drung inhibit microbial growth