ASSIGNED READING
| CHAPTER 1 |
pp 3-24 |
| Innate
immunity |
I6-11 |
| Phagocytosis |
65,68,467 |
| Phagocytic
deficiences |
|
| Inflammation |
357,
369-377 |
| Complement
|
348-353 |
| Lysozyme |
8, 10 |
| Interferon
(INF) |
460-461,
590-591, 373-375 |
| Tumour
necrosis factor (TNF) |
370-375 |
| NK Cells |
387-390 |
| NK Cells
and TNF |
391 |
| Phagocytic
deficiencies |
507-511 |
OUTLINE/SUMMARY
- Historical Perspective
- Discovery of humoral & cellular immunity
- Early theories
- Components of immunity
- Innate Immunity
- Anatomic Barriers
- Physiologic barriers
- Endocytic and phagocytic barriers
- Inflammatory response
- Acquired Immunity
- Cells of the immune system
- B cells
- T cells
- Antigen presenting cells (APC)
- Functions of immunity
- Antigen recognition
- Specificity
- MHC
- Processing & presentation of antigens
- Clonal selection
- Cellular interactions
- T helper cells
- humoral response
- cell mediated response
PERFORMANCE OBJECTIVES
DEFINE THE FOLLOWING KEY WORDS:
| Innate
immunity |
non
specific immunity |
lysozyme |
| interferon |
complement |
phagocytes |
| monocytes |
neutrophils |
natural
killer (NK) cells |
| Null
cells, |
chemotaxis |
diapedesis |
| phagocytosis |
primary
exposure |
secondary
exposure |
| mmunological
memory |
|
|
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Appreciate three functions of the immune system
- Distinguish between innate immunity and acquired immunity
- Discuss how thew clonal selective theory explains the
immune systems's
- ability to recognize millions of antigens
- Describe the basic structural and functional components
of the immune system
SHORT ANSWER QUESTIONS
- One of the functions of the immune system is
surveillance. What can happen to the host if surveillance
is naturally or artificially suppressed?
- How does clonal selection explain antibody diversity,
antibody specificity and immunologic memory?
- Why was the discovery of DNA structure important in
describing the development of humoral immunity?
- Differentiate between cell mediated and humoral immunity.
- LIST the cellular components required for a completed
immune system.
- Why are humans resistant to many animal diseases; for
example canine distemper, feline leukemia, and cowpox?
- Differentiate and discuss the characteristics of innate
immunity from those of acquired immunity.
- Differentiate between variolation and vaccination.
- Why is active immunity better than passive immunity?
- We exist in a preimmune state. Explain.
ASSIGNED
READING CHAPTER 3: pp 47-83
OUTLINE/SUMMARY
- Hematopoiesis
- hematopoietic Growth factors
- regulation of hematopoiesis
- enrichment of hematopoietic stem cells
- clinical uses of pluripotent stem cells
- Immune System Cells
- lymphoid cells
- mononuclear cells
- granulocytic cells
- mast cells
- dendritic cells
- Organs of the Immune System
- primary lymphoid organs
- lymphatic system
- secondary lymphoid organs
PERFORMANCE OBJECTIVES
DEFINE THE FOLLOWING KEY TERMS:
| Accessory cells |
activated macrophages |
Antibody depentdent cell mediated cytotoxicity (ADCC) |
| ntigen presenting cells (AAPCs) |
B cell |
Bone marrow |
| Bursa of Fabricius |
Cytotoxic T cells |
Dendritic cells |
| germinal centre |
Helper T cells |
hematopoiesis |
| monocytes |
lymphocytes |
High endothelial venules (HEVs) |
| Lymph node: |
lymphoid organs |
Large granular lymphocytes |
| natural killer cells |
plasma cells |
lymphoid system macrophages |
| primary follicles (nodules) |
secondary follicles |
mucoals associated lymphoid tissuse (MALT) |
| primary lymphoid organs |
T lymphocytes |
thymic hormones, |
| secondary lymphoid organs |
cortex |
Thymus dependent area |
| High endothelial venules |
Spleen |
thymus independent area |
| marginal zone |
afferent lymph vessels |
periarteriolar lymphoid sheath (PALS |
| medulla |
paracortex |
efferent lymph vessels |
| red pulp |
white pulp |
trabeculae |
| Thymus |
medulla |
|
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Describe the life history of leukocytes
- Construct a table to compare and contrast B Lymphocytes
and T lymphocytes with respect to structures, roles in
immunity, origin, maturation and location
- Differentiate among helper T cells, Cytotoxic T cells and
regulatory T cells
- Describe macrophages in terms of ther origin, location
and nomenclature
- Describe the role of macrophages in immunity
- Describe the role of dendritic cells
- Describe the characteristics of NK (Null cells)
- Describe the role of NK cells (Null cells) in Immunity
- Locate the different types of lymphoid tissues in the
body
- Differentiate betweeen primary and secondary lymphoid
organs
- Differentiates between bone marrow and thymus
- Differentiate among lymph nodes, spleen and MALT
- Compare the Bursa of Fabricius with Peyer's Patches
- Draw and label diagrams of the structure of the thymus,
lymph node, and spleen
- Interpret the role of the thymus in the establishment of
the immune system in the body.
SHORT ANSWER QUESTIONS
- Although the immune system has B cell and T cells, the
statement has been made " no T cells, no
immunity". Explain.
- Compare how null cells and cytotoxic T cells kill their
targets.
- Briefly describe the specific roles of helper and
cytotoxic T cells in normal immunity. Correlate these
roles with CD4+ T cells and CD8+ T cells.
- Unlike B cells and T cells, macrophages are neither
clonally restricted nor antigen specific. Explain.
Differentiate between primary and secondary lymphoid.
- Name four morphological areas of the lymph node and give
the cellular composition of each.
- Which area of the lymph node is called the thymus
independent area? Why?
- Which area of the lymph node is called the thymus
dependent area? Why?
- Describe T cell differentiation in the thymus using CD4
and CD8 markers.