| PHAGOCYTIC DEFICIENCIES | ||
| DISEASE | IMMUNE-SYSTEM DEFICIENCY | POSSIBLE MECHANISM |
| Congenital agranulocytosis | Decreased neutrophil count | Decreased production of G-CSF |
| Leukocyte-adhesion deficiency (LAD) |
Failure of neutrophils and monocytes to extravasate Defective CTL killing Defective T-cell help in B-cell activation |
Defective synthesis of b
chain of integrin adhesion molecules |
| Lazy-leukocyte syndrome | Decreased neutrophil chemotaxis | Not known |
| Chronic granulomatous disease (CGD) |
Defective killing by neutrophils of phagocytosed bacteria |
Decreased H2O2 production due to defective NADPH oxidase (cytochrome b) |