HLA ALLELES ASSOCIATED WITH INCREASED RISK FOR VARIOUS AUTOIMMUNE DISEASES |
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DISEASE | HLA ALLELE | RELATIVE RISK* |
Ankylosing spondylitis | B27 | 90 |
Goodpasture's syndrome |
DR2 | 16 |
Graves' disease | B8/DR3 | 3-4 |
Insulin-dependent diabetes mellitus |
DR4/DR3 DR3/DQW8 |
20 100 |
Juvenile rheumatoid arthritis |
B27/DR5 | 4 |
Multiple sclerosis | DR2 | 5 |
Myasthenia gravis | DR3 | 10 |
Pernicious anemia | DR5 | 5 |
Psoriatic arthritis (central) |
B27 | 11 |
Reiter's syndrome | B27 | 37 |
Rheumatoid arthritis | Dw4/DR4 | 10 |
Sjogren's syndrome | Dw3 | 6 |
Systemic lupus erythematosus (SLE) |
DR3 | 5 |
Ulcerative colitis | ZB5 | 4 |
* Likelihood of developing disease compared to the general population, which is assigned a risk value of 1. |