HLA ALLELES ASSOCIATED
WITH INCREASED RISK FOR VARIOUS
AUTOIMMUNE DISEASES
DISEASE HLA ALLELE RELATIVE RISK*
Ankylosing spondylitis B27 90
Goodpasture's
syndrome
DR2 16
Graves' disease B8/DR3 3-4
Insulin-dependent
diabetes mellitus
DR4/DR3
DR3/DQW8
20
100
Juvenile rheumatoid
arthritis
B27/DR5 4
Multiple sclerosis DR2 5
Myasthenia gravis DR3 10
Pernicious anemia DR5 5
Psoriatic arthritis
(central)
B27 11
Reiter's syndrome B27 37
Rheumatoid arthritis Dw4/DR4 10
Sjogren's syndrome Dw3 6
Systemic lupus
erythematosus (SLE)
DR3 5
Ulcerative colitis ZB5 4
* Likelihood of developing disease compared to the general population, which is assigned a risk value of 1.