| SOME AUTOIMMUNE DISEASES IN HUMANS | ||
| DISEASE | SELF-ANTIGEN | IMMUNE RESPONSE |
| ORGAN-SPECIFIC AUTOIMMUNE DISEASES | ||
| Addison's disease | Adrenal cells | Autoantibodies |
| Autoimmune hemolytic anemia | RBC membrane proteins | Autoantibodies |
| Goodpasture's syndrome | Renal and lung basement membranes |
Autoantibodies |
| Graves' disease | Thyroid-stimulating hormone receptor |
Autoantibody (stimulating) |
| Hashimoto's thyroiditis | Thyroid proteins and cells | TDTH cells, autoantibodies |
| Idiopathic thrombocytopenia purpura |
Platelet membrane proteins | Autoantibodies |
| Insulin-dependent diabetes mellitus |
Pancreatic beta cells | TDTH cells, autoantibodies |
| Mysasthenia gravis | Acetylcholine receptors | Autoantibody (blocking) |
| Myocardial infarction | Heart | Autoantibodies |
| Pernicious anemia | Gastric parietal cells; intrinsic factor |
Autoantibody |
| Poststreptococcal glomerulonephritis |
Kidney | Antigen-antibody complexes |
| Spontaneous infertility | Sperm | Autoantibodies |
| SYSTEMIC AUTOIMMUNE DISEASE | ||
| Ankylosing spondylitis | Vertebrae | Immune complexes |
| Multiple sclerosis | Brain or white matter | TDTH and TCcells, autoantibodies |
| Rheumatoid arthritis | Connective tissue, IgG | Autoantibodies, immune complexes |
| Scleroderma | Nuclei, heart, lungs, gastrointestinal tract, kidney |
Autoantibodies |
| Sjogren's syndrome | Salivary gland, liver, kidney, thyroid |
Autoantibodies |
| Systemic lupus erythematosus (SLE) | DNA, nuclear protein, RBC and platelet membranes |
Autoantibodies, immune complexes |