If you make people think that they think they will love
you BUT is you make them
really think they will hate you
Roscoe B. Ellard
Who am I? My research has
focused on the contetns of mast cell granules, their proteases
and their role in the local inflammatory responses of type I
hypersensitivity
- Allergy
- A description of "allergy" by a professor in
the Department of Microbiology at the University of
Kansas.
URL -->
http://falcon.cc.ukans.edu/~jbrown/allergy.html
- Allergy - Definition (Glossary of
Medical Terms)
- The definition of "allergy" from the Medical
College of Georgia's Glossary of Medical Terms.
URL
--> http://allergy.mcg.edu/glossary/glossary.html
- Allergy -- Health Care Professional
- This page is titled "The Immunologic Basis of
Allergic Diseases." This page is part of the
University of Texas - Houston, Department of Pathology
and Laboratory Medicine's Medical Education Information
Center (MEDIC(tm)).
URL -->
http://medic.med.uth.tmc.edu/hcprof/00000027.htm
- Allergy,
Asthma & Immunology Online
- Allergy, Asthma & Immunology Online is a
"news and information service" that is
maintained by a group of physicians at the Medical
College of Georgia.
URL -->
http://allergy.mcg.edu/
- Anaphylaxis
- This section on anaphylaxis is from the 16th edition
of The Merck Manual of Diagnosis and Therapy.
URL
-->
http://www.merck.com/!!tkyL82j4JtkyL82j4J/pubs/mmanual/html/pmieechb.htm
- Anti-Inflammatory, Antiallergic, and
Immunologic Drug Reviews
- This site, the Medical Science Bulletin (MSB) is
published by the Pharmaceutical Information Associates,
Ltd. Anti-Inflammatory, Antiallergic, and Immunologic
Drug Reviews are provided on this page.
URL
--> http://pharminfo.com/pubs/msb/msbanfl.html
- Blood Group Incompatibility -
Immunologic Diseases
- This site provides links to several articles
concerning blood group incompatibility (such as
Erythroblastosis fetalis). This section is contained in a
web site called "Galaxy - The Professional's Guide
to the World of Informaiton."
URL -->
http://www.einet.net:8000/galaxy/Medicine/Diseases-and-Disorders/Immunologic-Diseases/Blood-Group-Incompatibility.html
- Immunologic Diseases
- This is the Karolinska Institute Library and
Information Center web site on Immunologic Diseases. It
is a meta site containing links to many
immunology-related sites around the world.
URL
--> http://www.mic.ki.se/Diseases/c20.html
- Immunologic Disorders Due To
Hypersensitivity
- This section on immunolgic disorders due to
hypersensitivity is from the 16th edition of The
Merck Manual of Diagnosis and Therapy.
URL
-->
http://www.merck.com/!!tCeq40w64tCeq40w64/pubs/mmanual/html/ipkngkjd.htm
- Immunopathology Lecture Notes
- Located at Cornell University Medical Center, this
site provides lecture notes on Immunopathology. Topics
such as Type I Hypersensitivity (Anaphylaxis), Type II
Hypersensitivity (Antibody-Dependent), Type III
Hypersensitivity (Immune Complex Initiated), and Type IV
Hypersensitivity (Cell-Mediated) are covered as well as
numerous others.
URL -->
http://edcenter.med.cornell.edu/CUMC_PathNotes/Immunopathology/Immuno_TOC.html
- Food Allergy - Environmed Research Inc.
- This commercial site provides information about food
allergies and hypersensitivity.
URL -->
http://www.nutramed.com/zeno/immunology.htm
CHAPTER 17: pp 413-439
- Gell & Coombs Classification
- Type I Hypersensitivity: IgE mediatiated
- Components
- allergens
- IgE
- Mast cells & basophils
- IgE binding receptors
- Mechanisms
- receptor cross linkage
- intracellular events
- Mediators
- histamine
- leukotriens & prostoglandins
- cytokines
- Consequences
- systemic anaphylaxis
- localized anaphylaxis
- late phase reaction
- Regulation
- Detection
- Theraphy
- Type II Hypersensitivity: Antibody mediated cytotoxic
- Transfusion reactions
- Hemolytic disease of the newborn
- Drug induced hemolytic anemia
- Type II Hypersensitivity: Complex mediated cytotoxic
- Localized reactions
- Generalized reactions
- Type IV Hypersensitivity: DTH mediated
DEFINE THE FOLLOWING KEY WORDS:
| allergen |
allergy |
anaphylactic shock |
| anaphylaxis |
anergy |
contact sensitivity |
| basophils |
atopy |
delayed type hypersensitivity |
| degranulation |
hypersensitivity |
homocytotropic antibodies |
| desenstization |
hyposensitivity |
immediate hypersensitivity |
| granulomas |
late phase reaction |
mast cells |
| sensitization |
senstizing dose |
shocking dose |
| systemic anaphlyaxis |
triple response |
edema |
| erythema |
wheal and flare |
tubercles |
| Type I hypersensitivity |
tuberculosis |
tuberculin skin reaction |
| Type II hypersensitivity |
Type II hypersensitivity |
Type IV hypersensitivity |
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- List the Gell & Coombs classification for
hypersensitivity reactions; give examples of each type.
- Describe stimulatory hypersensitivity and give a specific
example
- Discuss the difference between primary and secondary
exposure to antigen in imunity and in hypersensitivity
- Describe the structural and functional characteristics of
IgE.
- Discuss the cytotropic nature of IgE
- Differentiate betweeen the cyclooxygenase and
lipoxygenase pathways of mediator production
- Describe the role of mast cells in immediate
hypersensitivity reactions.
- Distinguish between release of preformed and newly formed
mediators from mast cells and give examples of each type
of mediator
- Discuss the hallmarks of delayed type hypersensitivity
- Explain the mechanisms of Delayed Type Hypersensitivity
induction and development
- Distinguish between different types of Delayed type
hypersensitivity.
- Describe tuberculosis in terms of hypersensitivity
reactions.
- By derivation, what does allergy mean and what does
hypersensitivity mean? Are they synonymous?
- The main difference between immediate and delayed types
of hypersensivitiy is the time of appearance of the
reactions. True/False? If false, name the main
differences.
- What is the type II reaction described by Gell &
Cooombs? Does this reaction require complement?
- Is there a tendency to immediate hypersenstivity
reactions? Explain?
- Differentiate between antigen and allergen.
- What immune and nonimmune cells are involved in immediate
hypersensivity?
- What class of antibody in responsible for immediate
hypersenstivity?
- Describe some structural and biological characteristics
of this antibody?
- What do we mean by homocytotropic antibodies?
- Briefly describe the result of the interaction of IgE,
with mast cells
- in the presence of allergen.
- in the absence of allergen.
- What are the chemical mediators of immediate
hypersentivity reactions?
- Some effector molecules of immediate hypersensitivity
reactions are preformed mediators; others are newly
synthesized mediators.
- Distinguish between the two.
- Briefly describe the two pathways for the production of
newly synthesized mediators.
- How can you determine whether a person is allergic to a
foreign protein?
- What is the triple response?
- Name two "in vitro" test. W
- hat is the mechanism for desensitization for immediate
hypersensitivities?
- Is this desensitization lifelong?
- If not speculate on the reasons.
- What are some other modes of treatment for immediate
hypersensitivity?
- Describe the differences between systemic anahylaxis and
atopy?
- Are the mechanisms of cell-mediated immunity and DTH the
same?
- Name the effector cells in DTH.
- What are some of the hallmarks of DTH reactions?
- Describe contact sensitivity.
- How does contact sensitivity differ from the tuberculin
skin reaction?
- What is the mechanism of the tuberculin skin test?
- If the test is positive what causes the induration
(hardening) of the test site?
- What substances are used in this test?
- Name three different types of tuberculin skin tests?