A liberal arts education is
supposed to provide you with a value system, a standard,
a set of ideas, not a job
Caroline Bird
Who am I? I
established for the first time the role of the thymus and laid
the foundations of modern cellular immunology
- Microbial Toxins - Department of
Microbiology, University of Newcastle-upon-Tyne, UK
- This page contains information on microbial toxins
(including bacterial superantigens).
URL -->
http://monera.ncl.ac.uk/path/toxins.html
CHAPTER 12: pp 285-310
- T Cell Maturation
- Pre T cell receptor
- T cell development pathways
- Thymic Selection of T cells
- positive selection
- negative selection
- T helper Cell Activation
- TCR coupled signaling pathways
- Co-stimulatory signal
- Antagonists & Agonists
- Clonal Expansion
- Clonal Anergy
- Superantigens
- T Cell Differentiation
- Effector & memory cells
- Co-stimulatory differences
- Peripherial gamma delta T cells
- Distribution of cells
- Ligands recognized
- Functions
DEFINE THE FOLLOWING KEY TERMS:
| accessory molecules |
antigen processing |
associatve recogonition model |
| independent recognition model |
cell adhesion molecules |
subtractive hybrization |
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Outline antigen processing and presentation to TCR
- Describe the molecular pathways for T cell activation
- Describe positive and negative selection
- Discuss the role of accessory molecules in T cell antigen
recognition
- T cell proliferation and differentiation lead to
important immunological functions. What are they?
- Briefly discuss the molecular events, collected called
T-Cell activation, that lead to biologic function.
- What is the importance of diacylglycerol and IP3 in
T-cell activation?
- What transcription factors are involved in T cell
activation?