It is the function of a liberal
university not to give right answers, but to ask right questions
Cynthia Ozick
Who Am I? I
discovered that antigens must first be processed by macrophages
before the antigen can be recognized by T cells
| Presentation |
Slide show |
Web animation |
Download |
| Antigen Processing |
 |
|
|
Kuby's Immunology 4th Ed \chapter 8 pg201-214
Kuby's Immunology 3rd Ed Chapter 10: pp 249-262
- Self MHC Restriction of T Cells
- Role of Antigen Presenting Cells
- Two Presentation Pathways
- Cytosolic Pathway: Endogenous Antigens
- proteasomes
- peptide transport
- assembly of peptides in MHC-I
- Endocytic Pathway: Exogenous Antigens
- endocytic vesicles
- peptide transport
- Assembly of peptides in MHC-II
- Clinical Applications
| DEFINE
THE FOLLOWING KEY TERMS: |
| antigen presenting cells |
cytosolic pathway[] |
endocytic pathway[] |
| professional antigen presenting cells |
ubiquitin [] |
proteosome[] |
| nonprofessional antigen presenting cells |
calnexin[] |
invariant (Ii) chain [] |
| Transportors associated with antigen processing (TAP)
|
CLIP |
molecular chaperones[] |
QUESTIONS
- Describe self MHC restriction.
- Compare the cytosolic pathway for antigen presentation
with the endocytic pathway for antigen presentation
- Compare professional with non professional antigen
presenting cells.
- Draw a flow diagram comparing cytosolic and endocytic
pathways for processing antigens
- Describe peptide generation by proteasomes.
- Describe transport of antigenic peptides from the cytosol
to the Rough Endoplasmic reticulum
- Draw a concept map for the separate antigen presenting
pathways for endogenous and exogenous antigens.
- Describe the assembly of MHC-II molecules within the
Rough endoplasmic reticulum.
- Describe the development of a viral vaccine that uses the
cytosolic pathway.
- Describe the development of a vaccine that used