If
there is anything that we wish to change in the child,
we should first examine it and see whether it is not something
that could be better changed in ourselves.
Carl Jung
Everybody
likes a compliment
Abraham Lincoln
Who Am I? Trained as a
zoologist, I coined the term phagocyte after observing the
response of starfish larvae to rose thorns. I late showed that
white blood cells are phagocytic
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Lessons
for the first-year class in Histology, Vanderbilt University
Lessons for the first-year class in Histology. This site is
part of the Active Digital Library (ADL) project at Vanderbilt
University Medical Center. Below are some links to selected
images at this site.
URL --> http://www.mc.vanderbilt.edu/histo/blood/
CHAPTER 3: pp 47-83
- Hematopoiesis
- hematopoietic Growth factors
- regulation of hematopoiesis
- enrichment of hematopoietic stem cells
- clinical uses of pluripotent stem cells
- Immune System Cells
- lymphoid cells
- mononuclear cells
- granulocytic cells
- mast cells
- dendritic cells
- Organs of the Immune System
- primary lymphoid organs
- lymphatic system
- secondary lymphoid organs
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Describe the life history of leukocytes
- Construct a table to compare and contrast B Lymphocytes
and T lymphocytes with respect to structures, roles in
immunity, origin, maturation and location
- Differentiate among helper T cells, Cytotoxic T cells and
regulatory T cells
- Describe macrophages in terms of ther origin, location
and nomenclature
- Describe the role of macrophages in immunity
- Describe the role of dendritic cells
- Describe the characteristics of NK (Null cells)
- Describe the role of NK cells (Null cells) in Immunity
- Locate the different types of lymphoid tissues in the
body
- Differentiate betweeen primary and secondary lymphoid
organs
- Differentiates between bone marrow and thymus
- Differentiate among lymph nodes, spleen and MALT
- Compare the Bursa of Fabricius with Peyer's Patches
- Draw and label diagrams of the structure of the thymus,
lymph node, and spleen
- Interpret the role of the thymus in the establishment of
the immune system in the body.
| Accessory cells |
activated macrophages |
Antibody depentdent cell mediated cytotoxicity (ADCC) |
| ntigen presenting cells (AAPCs) |
B cell |
Bone marrow |
| Bursa of Fabricius |
Cytotoxic T cells |
Dendritic cells |
| germinal centre |
Helper T cells |
hematopoiesis |
| monocytes |
lymphocytes |
High endothelial venules (HEVs) |
| Lymph node: |
lymphoid organs |
Large granular lymphocytes |
| natural killer cells |
plasma cells |
lymphoid system macrophages |
| primary follicles (nodules) |
secondary follicles |
mucoals associated lymphoid tissuse (MALT) |
| primary lymphoid organs |
T lymphocytes |
thymic hormones, |
| secondary lymphoid organs |
cortex |
Thymus dependent area |
| High endothelial venules |
Spleen |
thymus independent area |
| marginal zone |
afferent lymph vessels |
periarteriolar lymphoid sheath (PALS |
| medulla |
paracortex |
efferent lymph vessels |
| red pulp |
white pulp |
trabeculae |
| Thymus |
medulla |
|
- Although the immune system has B cell and T cells, the
statement has been made " no T cells, no
immunity". Explain.
- Compare how null cells and cytotoxic T cells kill their
targets.
- Briefly describe the specific roles of helper and
cytotoxic T cells in normal immunity. Correlate these
roles with CD4+ T cells and CD8+ T cells.
- Unlike B cells and T cells, macrophages are neither
clonally restricted nor antigen specific. Explain.
Differentiate between primary and secondary lymphoid.
- Name four morphological areas of the lymph node and give
the cellular composition of each.
- Which area of the lymph node is called the thymus
independent area? Why?
- Which area of the lymph node is called the thymus
dependent area? Why?
- Describe T cell differentiation in the thymus using CD4
and CD8 markers.