Nothing
is more terrible than Ignorance in Action
Johann Wofgang von Goethe
Ignorance
is impotence, it is fear; it is cruelty:
it is all the things that make for unhappiness
Winifred Holtby
Who Am I? As
wife of the British Ambassador to Constantinople I observed the
benefical effects of variolation and applied them to my own
children.
Who am I? I
recognized that immunity to disease is not inherited by develops
gradually in the embryo. proposed the clonal selection theory and
was awarded the Nobel Prize in 1960
| Presentation |
Slide show |
Web animation |
Download |
| Innate Immunity |
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| Acquired Immunity |
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- Cells
Alive!
- CELLS alive! is posted on the WWW as an educational
service of Quill Graphics. Below are some links to
locations at Cells Alive! that may be of general interest
for Chapter 1 topics.
URL -->
http://www.cellsalive.com/
| CHAPTER 1 |
pp 3-24 |
| Innate
immunity |
I6-11 |
| Phagocytosis |
65,68,467 |
| Phagocytic
deficiences |
|
| Inflammation |
357,
369-377 |
| Complement
|
348-353 |
| Lysozyme |
8, 10 |
| Interferon
(INF) |
460-461,
590-591, 373-375 |
| Tumour
necrosis factor (TNF) |
370-375 |
| NK Cells |
387-390 |
| NK Cells
and TNF |
391 |
| Phagocytic
deficiencies |
507-511 |
- Historical Perspective
- Discovery of humoral & cellular immunity
- Early theories
- Components of immunity
- Innate Immunity
- Anatomic Barriers
- Physiologic barriers
- Endocytic and phagocytic barriers
- Inflammatory response
- Acquired Immunity
- Cells of the immune system
- B cells
- T cells
- Antigen presenting cells (APC)
- Functions of immunity
- Antigen recognition
- Specificity
- MHC
- Processing & presentation of antigens
- Clonal selection
- Cellular interactions
- T helper cells
- humoral response
- cell mediated response
ON COMPLETION OF THIS SECTION THE STUDENT SHOULD BE ABLE TO:
- Appreciate three functions of the immune system
- Distinguish between innate immunity and acquired immunity
- Discuss how thew clonal selective theory explains the
immune systems's
- ability to recognize millions of antigens
- Describe the basic structural and functional components
of the immune system
DEFINE THE FOLLOWING KEY WORDS:
| Innate
immunity |
non
specific immunity |
lysozyme |
| interferon |
complement |
phagocytes |
| monocytes |
neutrophils |
natural
killer (NK) cells |
| Null
cells, |
chemotaxis |
diapedesis |
| phagocytosis |
primary
exposure |
secondary
exposure |
| mmunological
memory |
|
|
- One of the functions of the immune system is
surveillance. What can happen to the host if surveillance
is naturally or artificially suppressed?
- How does clonal selection explain antibody diversity,
antibody specificity and immunologic memory?
- Why was the discovery of DNA structure important in
describing the development of humoral immunity?
- Differentiate between cell mediated and humoral immunity.
- LIST the cellular components required for a completed
immune system.
- Why are humans resistant to many animal diseases; for
example canine distemper, feline leukemia, and cowpox?
- Differentiate and discuss the characteristics of innate
immunity from those of acquired immunity.
- Differentiate between variolation and vaccination.
- Why is active immunity usually better than passive
immunity?
- We exist in a preimmune state. Explain.
- Describe the role and mechanism of action of
interferonsin the cancer immunotherapy 590-591
- Describe the role of complement in innate immunity
- Differentiate natural killer cells from B cells and T
cells
- Describe the stages of phagocytosis and its regulation
- Describe the stages of inflammation and its regulation
- Describe at least three phagocytic disorders, the
mechanistic basis of each and the consequences
- Describe the role and mechanism of action of
interferonsin the cancer immunotherapy 590-591
- Describe the role of complement in innate immunity
- Describe the stages of phagocytosis and its regulation
- Describe the stages of inflammation and its regulation
- Describe at least three phagocytic disorders, the
mechanistic basis of each and the consequences
- Describe the role of innate immunity during a primary
exposure
- Describe the role of innate immunity during a secondary
exposure
- Describe the mechanism of action of lysozyme
- Describe the role and mechanism of action of interferons
in the inflammatory response 373-375
- Describe the role and mechanism of action of interferons
in the virus infections 460-461